Schwarcz R, Meldrum B
Lancet. 1985 Jul 20;2(8447):140-3. doi: 10.1016/s0140-6736(85)90238-7.
Excessive excitation by neurotransmitters can cause the death of neurons. This excitotoxic action may be responsible for neuronal loss in stroke, cerebral palsy, epilepsy, ageing and Alzheimer's disease, Huntington's disease, and other chronic degenerative disorders. Compounds acting specifically to antagonise excitatory neurotransmission offer a novel therapeutic approach to these disorders.
神经递质的过度兴奋会导致神经元死亡。这种兴奋性毒性作用可能是中风、脑瘫、癫痫、衰老以及阿尔茨海默病、亨廷顿病和其他慢性退行性疾病中神经元丧失的原因。特异性拮抗兴奋性神经传递的化合物为这些疾病提供了一种新的治疗方法。
