Department of Neurology, High School of Science, Medical University of Silesia, Clinical Hospital No 7, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, Poland.
Department of Neurology, High School of Science, Medical University of Silesia, Clinical Hospital No 7, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, Poland.
Atherosclerosis. 2017 Aug;263:97-103. doi: 10.1016/j.atherosclerosis.2017.06.008. Epub 2017 Jun 3.
The inflammatory process (with TNFα, interleukin-6 and interleukin-10 involvement) plays a key role in the development, progression and destabilization of atherosclerotic plaques. The aim of this study was to assess the importance of double-checked measurements of TNFα, interleukin-6 (IL-6) and interleukin-10 (Il-10) serum levels in patients with internal carotid artery (ICA) stenosis to determine the dynamics of changes in the stenosis degree and in the ultrasound plaque morphology.
The study included 65 patients with ICA stenosis. Ultrasound of the carotid arteries was performed during qualification and every 3 months to identify any progression of stenosis degree and dynamics of changes in plaque morphology. Serum concentrations of TNF-alpha, IL-6 and IL-10 were measured during qualification and at month 6 of the study. Calculations considered cytokine concentrations and their indices determined as relative differences of cytokine levels assessed in the first and in second tests.
Patients with increasing degree of ICA stenosis had higher indices of IL-6 and IL-10 than patients without any increase in the stenosis degree. In patients with unfavorable dynamics of changes in plaque morphology, significantly higher levels of interleukin-6 were found in the second test; these patients had higher indices of IL-6 and IL-10 than patients with favorable dynamics of atherosclerotic plaque morphology on ultrasound.
Long-term trends in serum concentrations of IL-6 and IL-10 in patients with ICA stenosis allow to predict the progression of the degree of stenosis and the unfavorable change of atherosclerotic plaque morphology.
炎症过程（涉及 TNFα、白细胞介素-6 和白细胞介素-10）在动脉粥样硬化斑块的发展、进展和不稳定中起着关键作用。本研究旨在评估对内颈动脉（ICA）狭窄患者进行两次 TNFα、白细胞介素-6（IL-6）和白细胞介素-10（IL-10）血清水平检测的重要性，以确定狭窄程度和超声斑块形态变化的动态。
本研究纳入了 65 例 ICA 狭窄患者。在资格审查期间和每 3 个月进行颈动脉超声检查，以确定狭窄程度的进展和斑块形态变化的动态。在资格审查期间和研究的第 6 个月测量血清 TNF-α、IL-6 和 IL-10 浓度。计算考虑了细胞因子浓度及其指数，这些指数被确定为第一次和第二次测试中评估的细胞因子水平的相对差异。
ICA 狭窄程度增加的患者的 IL-6 和 IL-10 指数高于狭窄程度无增加的患者。在斑块形态变化不利的患者中，第二次测试中发现白细胞介素-6 水平显著升高；这些患者的 IL-6 和 IL-10 指数高于超声显示斑块形态呈有利变化的患者。
ICA 狭窄患者血清中 IL-6 和 IL-10 的长期趋势可预测狭窄程度的进展和动脉粥样硬化斑块形态的不利变化。
