Kfoury Miriana, Landy David, Ruellan Steven, Auezova Lizette, Greige-Gerges Hélène, Fourmentin Sophie
Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV, EA 4492), SFR Condorcet FR CNRS 3417, ULCO, F-59140 Dunkerque, France; Bioactive Molecules Research Group, Faculty of Sciences, Section II, Lebanese University, Lebanon.
Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV, EA 4492), SFR Condorcet FR CNRS 3417, ULCO, F-59140 Dunkerque, France.
Food Chem. 2017 Dec 1;236:41-48. doi: 10.1016/j.foodchem.2016.12.086. Epub 2016 Dec 29.
Nootkatone (NO) is a sesquiterpenoid volatile flavor, used in foods, cosmetics and pharmaceuticals, possessing also insect repellent activity. Its application is limited because of its low aqueous solubility and stability; this could be resolved by encapsulation in cyclodextrins (CDs). This study evaluated the encapsulation of NO by CDs using phase solubility studies, Isothermal Titration Calorimetry, Nuclear Magnetic Resonance spectroscopy and molecular modeling. Solid CD/NO inclusion complex was prepared and characterized for encapsulation efficiency and loading capacity using UV-Visible. Thermal properties were investigated by thermogravimetric-differential thermal analysis and release studies were performed using multiple headspace extraction. Formation constants (K) proved the formation of stable inclusion complexes. NO aqueous solubility, photo- and thermal stability were enhanced and the release could be insured from solid complex in aqueous solution. This suggests that CDs are promising carrier to improve NO properties and, consequently, to enlarge its use in foods, cosmetics, pharmaceuticals and agrochemicals preparations.
诺卡酮（NO）是一种倍半萜类挥发性风味物质，用于食品、化妆品和药品中，还具有驱虫活性。由于其低水溶性和稳定性，其应用受到限制；这可以通过包封在环糊精（CDs）中来解决。本研究使用相溶解度研究、等温滴定量热法、核磁共振光谱和分子建模评估了CDs对NO的包封。制备了固体CD/NO包合物，并使用紫外可见光谱对包封效率和负载量进行了表征。通过热重-差热分析研究了热性质，并使用多顶空萃取进行了释放研究。形成常数（K）证明了稳定包合物的形成。NO的水溶性、光稳定性和热稳定性得到了提高，并且可以确保从固体复合物在水溶液中释放。这表明CDs是改善NO性质的有前途的载体，因此可以扩大其在食品、化妆品、药品和农用化学品制剂中的应用。
