纳武单抗治疗晚期非小细胞肺癌患者症状性软脑膜转移的疗效改善
Symptomatic leptomeningeal metastasis improvement with nivolumab in advanced non-small cell lung cancer patient.
作者信息
Gion Maria, Remon Jordi, Caramella Caroline, Soria Jean-Charles, Besse Benjamin
机构信息
Department of Cancer Medicine, Gustave Roussy, Villejuif, France; Hospital Ramon y Cajal, Madrid, Spain.
Department of Cancer Medicine, Gustave Roussy, Villejuif, France.
出版信息
Lung Cancer. 2017 Jun;108:72-74. doi: 10.1016/j.lungcan.2017.02.022. Epub 2017 Feb 27.
Leptomeningeal metastasis (LM) is reported in 3.8% of non-small-cell lung cancer (NSCLC) patients, more frequently in adenocarcinoma, and it correlates with poor prognosis. Data regarding the activity of immune checkpoint inhibitors in LM is lacking. We present a case report about the efficacy of nivolumab in a patient with advanced NSCLC and symptomatic LM.
据报道，软脑膜转移（LM）在3.8%的非小细胞肺癌（NSCLC）患者中出现，在腺癌中更为常见，且与预后不良相关。关于免疫检查点抑制剂在软脑膜转移中的活性的数据尚缺。我们报告一例关于纳武单抗治疗一名晚期非小细胞肺癌合并有症状软脑膜转移患者的疗效的病例。
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