Ahmad Iqbal, Sabah Arif, Anwar Zubair, Arif Aysha, Arsalan Adeel, Qadeer Kiran
Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi, Pakistan.
Faculty of Pharmacy, Ziauddin Medical University, 4/B, Shahrah-e-Ghalib, Block 6, Clifton, Karachi, Pakistan.
Pak J Pharm Sci. 2017 Jan;30(1 Suppl):247-252.
A study of the extraction of polymeric material and dyes from the pharmaceutical plastic containers using various organic solvents was conducted to evaluate the effect of polarity on the extraction process. The plastic containers used included semi-opaque, opaque, transparent and amber colored and the solvent used were acetonitrile, methanol, ethanol, acetone, dichloroethane, chloroform and water. The determination of extractable material was carried out by gravimetric and spectrometric methods. The yield of extractable materials from containers in 60 h was 0.10-1.29% (w/w) and the first-order rate constant (kobs) for the extraction of polymeric material ranged from 0.52-1.50 × 10-3 min and for the dyes 6.43- 6.74 x10-3min-1. The values of (k) were found to be an inverse function of solvent dielectric constant and decreased linearly with the solvent acceptor number. The extractable polymeric materials exhibited absorption in the 200-400 nm region and the dyes in the 300-500nm region. The rates of extraction of polymeric material and dyes from plastic containers were dependent on the solvent dielectric constant. The solvents of low polarity were more effective in the extraction of material indicating that the extracted material were of low polarity or have non-polar character. The dyes were soluble in acetone and chloroform. No plastic material was found to be extracted from the containers in aqueous solution.
开展了一项关于使用各种有机溶剂从药用塑料容器中提取聚合物材料和染料的研究，以评估极性对提取过程的影响。所使用的塑料容器包括半透明、不透明、透明和琥珀色的，所使用的溶剂为乙腈、甲醇、乙醇、丙酮、二氯乙烷、氯仿和水。可提取物的测定采用重量法和光谱法。60小时内从容器中提取的材料产率为0.10 - 1.29%（w/w），聚合物材料提取的一级速率常数（kobs）范围为0.52 - 1.50×10⁻³ min⁻¹，染料的为6.43 - 6.74×10⁻³ min⁻¹。发现（k）值是溶剂介电常数的反函数，并随溶剂受体数呈线性下降。可提取的聚合物材料在200 - 400 nm区域有吸收，染料在300 - 500 nm区域有吸收。从塑料容器中提取聚合物材料和染料的速率取决于溶剂介电常数。低极性溶剂在材料提取方面更有效，这表明提取的材料极性较低或具有非极性特征。染料可溶于丙酮和氯仿。在水溶液中未发现有塑料材料从容器中被提取出来。
