Shi Yulan, Ying Xiao, Hu Xiaoye, Shen Hong
Department of Surgical Oncology, the Second Affiliated Hospital, Zhejiang University School of Medicine, China.
Department of medical Oncology, the Second Affiliated Hospital, Zhejiang University School of Medicine, China.
Pak J Pharm Sci. 2017 Jan;30(1 Suppl):303-307.
This study was performed to evaluate cancer pain control of high-Intensity focused ultrasound ablation (HIFU) and to manage the HIFU treatment pain in advanced pancreatic cancer patients with analgesics. We collected 71 locally advanced pancreatic cancer patients treated with HIFU from 2013 March to 2014 January in our hospital. The cancer pain (pre-HIFU and two weeks after HIFU) and HIFU treatment pain were evaluated respectively. The numeric rating scale (NRS) was used as the tool of pain evaluation. The related factors with pains were analyzed. The 70.42% cancer painless rate before HIFU was improved to 92.96% (P<0.05) 2 weeks after HIFU in 71 advanced pancreatic cancer patents without analgesics adjustment. The HIFU treatment pain occurred in 42 of 71 treated patients (59.15 %). The average duration was 3.93 days and pain score was 3.22. HIFU can improve cancer pain relief further in the advanced pancreatic cancer patients with third ladder analgesics, meanwhile HIFU treatment pain can be managed easy because of its short duration and low pain score.
本研究旨在评估高强度聚焦超声消融(HIFU)对癌症疼痛的控制效果,并使用镇痛药管理晚期胰腺癌患者的HIFU治疗疼痛。我们收集了2013年3月至2014年1月在我院接受HIFU治疗的71例局部晚期胰腺癌患者。分别评估了癌症疼痛(HIFU治疗前和HIFU治疗后两周)和HIFU治疗疼痛。采用数字评分量表(NRS)作为疼痛评估工具。分析了与疼痛相关的因素。71例晚期胰腺癌患者在未调整镇痛药的情况下,HIFU治疗前癌症无痛率为70.42%,HIFU治疗后2周提高至92.96%(P<0.05)。71例接受治疗的患者中有42例(59.15%)出现了HIFU治疗疼痛。平均持续时间为3.93天。疼痛评分为3.22。HIFU可进一步改善晚期胰腺癌患者使用第三阶梯镇痛药时的癌症疼痛缓解情况,同时,HIFU治疗疼痛持续时间短、疼痛评分低,易于管理。