Stojanovska Jadranka, Ibrahim El-Sayed H, Chughtai Aamer R, Jackson Elizabeth A, Gross Barry H, Jacobson Jon A, Tsodikov Alexander, Daneshvar Brian, Long Benjamin D, Chenevert Thomas L, Kazerooni Ella A
Department of Radiology, University of Michigan, Ann Arbor, Michigan.
Tomography. 2017 Mar;3(1):33-40. doi: 10.18383/j.tom.2017.00103.
Intrathoracic fat volume, more specifically, epicardial fat volume, is an emerging imaging biomarker of adverse cardiovascular events. The purpose of this work is to show the feasibility and reproducibility of intrathoracic fat volume measurement applied to contrast-enhanced multidetector computed tomography images. A retrospective cohort study of 62 subjects free of cardiovascular disease (55% females, age = 49 ± 11 years) conducted from 2008 to 2011 formed the study group. Intrathoracic fat volume was defined as all fat voxels measuring -50 to -250 Hounsfield Unit within the intrathoracic cavity from the level of the pulmonary artery bifurcation to the heart apex. The intrathoracic fat was separated into epicardial and extrapericardial fat by tracing the pericardium. The measurements were obtained by 2 readers and compared for interrater reproducibility. The fat volume measurements for the study group were 141 ± 72 cm for intrathoracic fat, 58 ± 27 cm for epicardial fat, and 84 ± 50 cm for extrapericardial fat. There was no statistically significant difference in intrathoracic fat volume measurements between the 2 readers, with correlation coefficients of 0.88 ( = .55) for intrathoracic fat volume and -0.12 ( = .33) for epicardial fat volume. Voxel-based measurement of intrathoracic fat, including the separation into epicardial and extrapericardial fat, is feasible and highly reproducible from multidetector computed tomography scans.
胸腔脂肪体积，更具体地说是心外膜脂肪体积，是一种新兴的不良心血管事件的影像生物标志物。这项工作的目的是展示应用于对比增强多排计算机断层扫描图像的胸腔脂肪体积测量的可行性和可重复性。2008年至2011年对62名无心血管疾病的受试者（55%为女性，年龄 = 49 ± 11岁）进行的回顾性队列研究构成了研究组。胸腔脂肪体积定义为从肺动脉分叉水平至心尖的胸腔内所有测量值在-50至-250亨氏单位之间的脂肪体素。通过描绘心包将胸腔脂肪分为心外膜脂肪和心包外脂肪。测量由2名阅片者进行，并比较阅片者间的可重复性。研究组的脂肪体积测量结果为：胸腔脂肪141 ± 72 cm，心外膜脂肪58 ± 27 cm，心包外脂肪84 ± 50 cm。两名阅片者之间胸腔脂肪体积测量无统计学显著差异，胸腔脂肪体积的相关系数为0.88（P = 0.55），心外膜脂肪体积的相关系数为-0.12（P = 0.33）。基于体素的胸腔脂肪测量，包括将其分为心外膜脂肪和心包外脂肪，从多排计算机断层扫描中是可行且高度可重复的。
