Zhang Huiqing, Yang Geliang, Zhang Wei, Gu Wei, Su Yonghua, Ling Changquan
1 Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai, China.
2 Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Integr Cancer Ther. 2018 Jun;17(2):551-557. doi: 10.1177/1534735417696722. Epub 2017 Mar 15.
Complementary and alternative medicine (CAM) has been widely used by cancer patients and oncologists in the past decades. The present study aimed to examine and compare the characteristics and registration status of published studies in a sample of recently published CAM randomized controlled trial (RCT) reports of oncology in leading journals of 3 categories: general and internal medicine (GIM), clinical oncology (CO), and CAM.
Articles published in the top 5 journals of the 3 categories from 2006 to 2015 were searched in PubMed. Basic characteristics, registration information, impact factor, and citations were identified and extracted from the included RCTs. Data were summarized by frequency, mean, and median and compared using χ test and Kruskal-Wallis H test.
A total of 59 RCTs were included; among them, 34 (58%) could be identified with a registration number. GIM journals (15) enjoyed the highest average number of citations per article, followed by CO (12) and CAM (3) journals ( P < .0001). ClinicalTrials.gov was the most popular registry for these RCTs. Of the RCTs registered in ClinicalTrials.gov , 24% (4/17) of the published studies in CO journals put their results in the registry; however, no study in GIM and CAM journals put the result in the registry ( P = .372).
The top GIM, CO, and CAM journals rarely published CAM RCTs of oncology from 2006 to 2015, and the CAM articles of oncology were less cited. However, there was a clear improvement in the trial registration rate over the past decades.
在过去几十年中，补充和替代医学（CAM）已被癌症患者和肿瘤学家广泛使用。本研究旨在检查和比较三类领先期刊（普通内科和内科医学（GIM）、临床肿瘤学（CO）和补充和替代医学（CAM））中最近发表的肿瘤学CAM随机对照试验（RCT）报告样本中已发表研究的特征和注册状态。
在PubMed中搜索2006年至2015年这三类排名前五的期刊上发表的文章。从纳入的随机对照试验中识别并提取基本特征、注册信息、影响因子和引用次数。数据通过频率、均值和中位数进行汇总，并使用χ检验和Kruskal-Wallis H检验进行比较。
共纳入59项随机对照试验；其中34项（58%）可以识别到注册号。GIM期刊（15种）每篇文章的平均引用次数最高，其次是CO期刊（12种）和CAM期刊（3种）（P <.0001）。ClinicalTrials.gov是这些随机对照试验最常用的注册平台。在ClinicalTrials.gov注册的随机对照试验中，CO期刊上24%（4/17）的已发表研究将其结果登记在该平台；然而，GIM和CAM期刊上没有研究将结果登记在该平台（P = 0.372）。
2006年至2015年期间，顶级GIM、CO和CAM期刊很少发表肿瘤学的CAM随机对照试验，肿瘤学的CAM文章被引用的次数较少。然而，在过去几十年中，试验注册率有了明显提高。
