Department of Pathology, Nantong University, Nantong, Jiangsu 226001, P.R. China.
Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Targets, Nantong University, Nantong, Jiangsu 226001, P.R. China.
Int J Mol Med. 2017 Aug;40(2):491-498. doi: 10.3892/ijmm.2017.3023. Epub 2017 Jun 13.
Gliomas are the most common primary brain tumors of the central nervous system (CNS). Due to the poor prognosis of glioma patients, it is urgent to develop more effective therapies. Deltex-3-like (DTX3L), also known as B-lymphoma and BAL-associated protein (BBAP), has been reported to play an important role in the progression of many tumors. This study aimed to investigate the clinical significance and biological function of DTX3L in human glioma. Clinically, the protein expression level of DTX3L is increased in glioma tissues compared with that observed in normal brain tissues. Immunohistochemical analysis demonstrated that DTX3L was highly expressed in the glioma tissues and its level was correlated with the grade of malignancy. Multivariate analysis revealed the association between high expression of DTX3L and the poor prognosis of glioma patients. In addition, knockdown of DTX3L by siRNA transfection increased glioma cell apoptosis. Moreover, suppression of DTX3L expression was shown to significantly inhibit the migration and invasion of glioma cells. These data indicate that DTX3L plays an important role in the pathogenic process of glioma, suggesting that DTX3L could be a potential prognostic biomarker for glioma.
神经胶质瘤是中枢神经系统（CNS）最常见的原发性脑肿瘤。由于神经胶质瘤患者的预后较差，因此迫切需要开发更有效的治疗方法。Deltex-3 样（DTX3L），也称为 B 细胞淋巴瘤和 BAL 相关蛋白（BBAP），据报道在许多肿瘤的进展中发挥重要作用。本研究旨在探讨 DTX3L 在人神经胶质瘤中的临床意义和生物学功能。临床上，与正常脑组织相比，神经胶质瘤组织中 DTX3L 的蛋白表达水平增加。免疫组织化学分析表明，DTX3L 在神经胶质瘤组织中高表达，其水平与恶性程度相关。多因素分析显示，DTX3L 高表达与神经胶质瘤患者的不良预后相关。此外，通过 siRNA 转染敲低 DTX3L 可增加神经胶质瘤细胞凋亡。此外，抑制 DTX3L 的表达可显著抑制神经胶质瘤细胞的迁移和侵袭。这些数据表明 DTX3L 在神经胶质瘤的发病机制中起重要作用，提示 DTX3L 可能是神经胶质瘤的潜在预后生物标志物。
