血管生成素-2、内皮糖蛋白和胎盘生长因子在HIV相关先兆子痫中的作用。
Role of angiopoietin-2, endoglin, and placental growth factor in HIV-associated preeclampsia.
作者信息
Mbhele Nokuzola, Moodley Jagidesa, Naicker Thajasvarie
机构信息
a Optics and Imaging Centre, Doris Duke Medical Research Institute , University of KwaZulu-Natal , Durban , South Africa.
b Woman's Health and HIV Research Group , University of KwaZulu-Natal , Durban , South Africa.
出版信息
Hypertens Pregnancy. 2017 Aug;36(3):240-246. doi: 10.1080/10641955.2017.1326506. Epub 2017 Jun 19.
OBJECTIVE
The factors angiopoeitin-2 (Ang-2), endoglin (Eng), and placental growth factor (PlGF) have been implicated in the pathophysiology of preeclampsia (PE). This study assessed their serum levels in HIV-negative and HIV-positive pregnant normotensive and pre-eclamptic women.
METHODS
Participants were recruited at the antenatal clinic, serum samples were evaluated using the Bioplex Human Cancer Biomarker (panel 2).
RESULTS
Ang-2 and Eng levels were higher, whilst PlGF levels were lower in the PE compared with the normotensive group. Pregnancy type had no significant effect on Ang-2 and showed a significant interaction with Eng (p < 0.0001) and PlGF (p = 0.0033). HIV status had no significant effect on angiopoeitin-2 (p = 0.4), Eng (p = 0.4), and PlGF (p = 0.7) but the levels were slightly higher in the HIV-negative cohort.
CONCLUSIONS
This study demonstrates an elevation of Ang-2 and Eng in pre-eclamptic compared with normotensive pregnant women implicating their role in its pathogenesis.
目的
血管生成素-2（Ang-2）、内皮糖蛋白（Eng）和胎盘生长因子（PlGF）等因子与子痫前期（PE）的病理生理学有关。本研究评估了HIV阴性和HIV阳性的血压正常及子痫前期孕妇血清中这些因子的水平。
方法
在产前诊所招募参与者，使用Bioplex人类癌症生物标志物（第2组）评估血清样本。
结果
与血压正常组相比，子痫前期组的Ang-2和Eng水平较高，而PlGF水平较低。妊娠类型对Ang-2无显著影响，但与Eng（p < 0.0001）和PlGF（p = 0.0033）存在显著交互作用。HIV状态对血管生成素-2（p = 0.4）、Eng（p = 0.4）和PlGF（p = 0.7）无显著影响，但HIV阴性队列中的水平略高。
结论
本研究表明，与血压正常的孕妇相比，子痫前期孕妇的Ang-2和Eng升高，提示它们在子痫前期发病机制中的作用。
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