Sahu Pramod K, Jarhad Dnyandev B, Kim Gyudong, Jeong Lak Shin
Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Seoul, South Korea.
Curr Protoc Nucleic Acid Chem. 2017 Jun 19;69:14.13.1-14.13.15. doi: 10.1002/cpnc.27.
5'-Homo-4'-selenonucleosides, a class of next-generation nucleosides, are synthesized from D-ribose via a 4-selenosugar intermediate. The key step in synthesizing this intermediate is a seleno-Michael reaction. 5'-Homo-4'-selenouridine and -adenosine are prepared using Pummerer-type and Vorbrüggen condensation, respectively. © 2017 by John Wiley & Sons, Inc.
5'-高-4'-硒代核苷是一类下一代核苷，由D-核糖经4-硒代糖中间体合成。合成该中间体的关键步骤是硒代迈克尔反应。5'-高-4'-硒代尿苷和5'-高-4'-硒代腺苷分别通过普默勒型反应和福尔布吕根缩合反应制备。© 2017约翰·威利父子公司版权所有
