通过硒迈克尔反应立体选择性合成4'-硒代核苷。

Stereoselective Synthesis of 4'-Selenonucleosides via the Seleno-Michael Reaction.

作者信息

Sahu Pramod K, Jarhad Dnyandev B, Kim Gyudong, Jeong Lak Shin

机构信息

Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Seoul, South Korea.

出版信息

Curr Protoc Nucleic Acid Chem. 2017 Jun 19;69:14.13.1-14.13.15. doi: 10.1002/cpnc.27.

DOI:10.1002/cpnc.27

PMID:28628205

Abstract

5'-Homo-4'-selenonucleosides, a class of next-generation nucleosides, are synthesized from D-ribose via a 4-selenosugar intermediate. The key step in synthesizing this intermediate is a seleno-Michael reaction. 5'-Homo-4'-selenouridine and -adenosine are prepared using Pummerer-type and Vorbrüggen condensation, respectively. © 2017 by John Wiley & Sons, Inc.

摘要