Marrie Thomas J, Tyrrell Gregory J, Majumdar Sumit R, Eurich Dean T
Emerg Infect Dis. 2017 Jul;23(7):1118-1123. doi: 10.3201/eid2307.161858.
Little is known about concurrent infection with hepatitis C virus (HCV) and Streptococcus pneumoniae, which causes invasive pneumococcal disease (IPD). We hypothesized that co-infection with HCV and S. pneumoniae would increase risk for death and complications. We captured sociodemographic and serologic data for adults with IPD in a population-based cohort study in northern Alberta, Canada, during 2000-2014. IPD patients infected with HCV were compared with IPD patients not infected with HCV for risk of in-hospital deaths and complications by using multivariable logistic regression. A total of 355 of 3,251 patients with IPD were co-infected with HCV. The in-hospital mortality rate was higher for IPD patients infected with HCV. Prevalence of most IPD-related complications (e.g., cellulitis, acute kidney injury, mechanical ventilation) was also higher in HCV-infected patients. Infection with HCV is common in patients with IPD, and HCV is independently associated with an increased risk for serious illness and death.
关于丙型肝炎病毒（HCV）与导致侵袭性肺炎球菌病（IPD）的肺炎链球菌的合并感染，人们了解甚少。我们推测，HCV与肺炎链球菌的合并感染会增加死亡和并发症风险。在2000年至2014年期间，我们在加拿大艾伯塔省北部开展了一项基于人群的队列研究，收集了IPD成年患者的社会人口学和血清学数据。通过多变量逻辑回归，比较了感染HCV的IPD患者与未感染HCV的IPD患者的院内死亡和并发症风险。在3251例IPD患者中，共有355例合并感染HCV。感染HCV的IPD患者的院内死亡率更高。在感染HCV的患者中，大多数与IPD相关的并发症（如蜂窝织炎、急性肾损伤、机械通气）的发生率也更高。HCV感染在IPD患者中很常见，并且HCV与严重疾病和死亡风险增加独立相关。
