Rudnick Samuel B, Zabriskie Hannah, Ho Justin, Gurnett Christina A, Dobbs Matthew B
Departments of Orthopaedic Surgery.
Neurology.
J Pediatr Orthop B. 2018 Mar;27(2):147-151. doi: 10.1097/BPB.0000000000000473.
Does scoliosis severity increase scoliosis risk or severity in relatives? In a cohort of 1257 severe idiopathic scoliosis patients, the percentage with at least one affected relative was compared across the categories of patient sex, major curve severity (Cobb angle), and treatment method. In total, 138 (11%) of 1257 patients had at least one affected first-degree relative and 59 (5%) had at least one affected second-degree relative. As expected, males were more likely to have affected first-degree relatives than females (18 vs. 10% with a risk difference of -0.0864) [95% confidence interval (CI): -0.14 to -0.03; P=0.0002]. However, the major curve severity of the patient (<25°, 25°-49°, and ≥50°) did not impact the prevalence of having at least one affected relative (P=0.69). Surgically treated patients had no greater risk than nonsurgically treated patients of having either an affected relative or a surgically treated relative [11 vs. 11% (odds ratio: 0.912; 95% CI: 0.640-1.299, P=0.61), 6 vs. 5% (OR: 0.788; 95% CI: 0.485-1.280, P=0.34), respectively]. Therefore, our data suggest that scoliosis severity does not independently influence the risk of either scoliosis or its severity in family members.
脊柱侧弯的严重程度会增加亲属患脊柱侧弯的风险或严重程度吗？在一个由1257名重度特发性脊柱侧弯患者组成的队列中，比较了患者性别、主弯严重程度（Cobb角）和治疗方法类别中至少有一名受影响亲属的患者百分比。在1257名患者中，共有138名（11%）至少有一名受影响的一级亲属，59名（5%）至少有一名受影响的二级亲属。正如预期的那样，男性比女性更有可能有受影响的一级亲属（分别为18%和10%，风险差异为-0.0864）[95%置信区间（CI）：-0.14至-0.03；P=0.0002]。然而，患者的主弯严重程度（<25°、25°-49°和≥50°）并未影响至少有一名受影响亲属的患病率（P=0.69）。接受手术治疗的患者与未接受手术治疗的患者相比，有受影响亲属或接受手术治疗亲属的风险并无增加[分别为11%和11%（优势比：0.912；95%CI：0.640-1.299，P=0.61），6%和5%（OR：0.788；95%CI：0.485-1.280，P=0.34）]。因此，我们的数据表明，脊柱侧弯严重程度并不会独立影响家庭成员患脊柱侧弯的风险或其严重程度。
