Walczak Maciej A, Zhu Feng
Department of Chemistry and Biochemistry, University of Colorado, 215 UCB, Boulder, CO, 80309, USA.
Chembiochem. 2017 Sep 19;18(18):1789-1791. doi: 10.1002/cbic.201700311. Epub 2017 Aug 9.
31+30+31: Ye and colleagues have synthesized a branched 92-mer of arabinogalactan-a major component of the cell wall of M. tuberculosis-by linking a linear oligogalactan 30-mer with two d-arabinofuranose 31-mers. Their approach capitalizes on sequential, one-pot glycosylation reactions that result in a rapid increase in molecular complexity and efficient synthesis of a branched oligosaccharide.
31 + 30 + 31：Ye及其同事通过将线性寡聚半乳糖30聚体与两个D-阿拉伯呋喃糖31聚体连接，合成了一种分枝的92聚体阿拉伯半乳聚糖（结核分枝杆菌细胞壁的主要成分）。他们的方法利用了顺序的一锅法糖基化反应，该反应导致分子复杂性迅速增加，并能高效合成分枝寡糖。
