非自杀性自伤青少年的多模态神经影像学：杏仁核功能连接性
Multi-modal neuroimaging of adolescents with non-suicidal self-injury: Amygdala functional connectivity.
作者信息
Westlund Schreiner Melinda, Klimes-Dougan Bonnie, Mueller Bryon A, Eberly Lynn E, Reigstad Kristina M, Carstedt Patricia A, Thomas Kathleen M, Hunt Ruskin H, Lim Kelvin O, Cullen Kathryn R
机构信息
Department of Psychology, University of Minnesota College of Liberal Arts, United States.
Department of Psychology, University of Minnesota College of Liberal Arts, United States.
出版信息
J Affect Disord. 2017 Oct 15;221:47-55. doi: 10.1016/j.jad.2017.06.004. Epub 2017 Jun 13.
BACKGROUND
Non-suicidal self-injury (NSSI) is a significant mental health problem among adolescents. Research is needed to clarify the neurobiology of NSSI and identify candidate neurobiological targets for interventions. Based on prior research implicating heightened negative affect and amygdala hyperactivity in NSSI, we pursued a systems approach to characterize amygdala functional connectivity networks during rest (resting-state functional connectivity [RSFC)]) and a task (task functional connectivity [TFC]) in adolescents with NSSI.
METHOD
We examined amygdala networks in female adolescents with NSSI and healthy controls (n = 45) using resting-state fMRI and a negative emotion face-matching fMRI task designed to activate the amygdala. Connectivity analyses included amygdala RSFC, amygdala TFC, and psychophysiological interactions (PPI) between amygdala connectivity and task conditions.
RESULTS
Compared to healthy controls, adolescents with NSSI showed atypical amygdala-frontal connectivity during rest and task; greater amygdala RSFC in supplementary motor area (SMA) and dorsal anterior cingulate; and differential amygdala-occipital connectivity between rest and task. After correcting for depression symptoms, amygdala-SMA RSFC abnormalities, among others, remained significant.
LIMITATIONS
This study's limitations include its cross-sectional design and its absence of a psychiatric control group.
CONCLUSIONS
Using a multi-modal approach, we identified widespread amygdala circuitry anomalies in adolescents with NSSI. While deficits in amygdala-frontal connectivity (driven by depression symptoms) replicates prior work in depression, hyperconnectivity between amygdala and SMA (independent of depression symptoms) has not been previously reported. This circuit may represent an important mechanism underlying the link between negative affect and habitual behaviors. These abnormalities may represent intervention targets for adolescents with NSSI.
背景
非自杀性自伤（NSSI）是青少年中一个重要的心理健康问题。需要开展研究以阐明NSSI的神经生物学机制，并确定干预的候选神经生物学靶点。基于先前有关NSSI中负性情绪增强和杏仁核过度活跃的研究，我们采用系统方法来表征NSSI青少年在静息状态（静息态功能连接[RSFC]）和一项任务（任务态功能连接[TFC]）期间的杏仁核功能连接网络。
方法
我们使用静息态功能磁共振成像（fMRI）以及一项旨在激活杏仁核的负性情绪面部匹配fMRI任务，对患有NSSI的女性青少年和健康对照者（n = 45）的杏仁核网络进行了检查。连接性分析包括杏仁核RSFC、杏仁核TFC以及杏仁核连接与任务条件之间的心理生理交互作用（PPI）。
结果
与健康对照者相比，患有NSSI的青少年在静息和任务期间表现出非典型的杏仁核 - 额叶连接；辅助运动区（SMA）和背侧前扣带回中杏仁核RSFC更强；静息和任务期间杏仁核 - 枕叶连接存在差异。在校正抑郁症状后，杏仁核 - SMA RSFC异常等仍具有显著性。
局限性
本研究的局限性包括其横断面设计以及缺乏精神疾病对照组。
结论
通过多模态方法，我们在患有NSSI的青少年中发现了广泛的杏仁核神经回路异常。虽然杏仁核 - 额叶连接缺陷（由抑郁症状驱动）重复了先前在抑郁症中的研究结果，但杏仁核与SMA之间的高连接性（独立于抑郁症状）此前尚未见报道。该神经回路可能是负性情绪与习惯性行为之间联系的重要潜在机制。这些异常可能是NSSI青少年的干预靶点。
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