Department of Chemistry, Jinan University, Guangzhou 510632, PR China.
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, PR China.
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:185-190. doi: 10.1016/j.msec.2017.05.054. Epub 2017 May 10.
A major problem associated with colon cancer is liver metastasis. A colon-targeted drug delivery system is one way to address this problem after the resection of colorectal cancer. However, traditional drug delivery systems face many challenges, such as an inability to control the release rate, inaccurate targeting, susceptibility to the microenvironment and poor stability. Here, we report the development of a graphene oxide (GO)-based, sodium alginate (ALG) functionalized colon-targeting drug delivery system, that is loaded with 5-fluorouracil (5-FU) as the anti-cancer drug (denoted as GO-ALG/5-FU). Our results demonstrate that the as-prepared drug delivery system possesses a much lower toxicity and better colon-targeting controlled-release behaviours. We show that GO-ALG/5-FU significantly inhibited tumour growth and liver metastasis and prolonged the survival time of mice. We anticipate that our assay will help improve basic research of colon-targeted drug delivery systems and provide a new way to treat colon cancer liver metastasis.
与结肠癌相关的一个主要问题是肝转移。结直肠肿瘤切除术后，结肠靶向药物递送系统是解决该问题的一种方法。然而，传统的药物递送系统面临许多挑战，例如无法控制释放速度、靶向不准确、易受微环境影响和稳定性差。在这里，我们报告了一种基于氧化石墨烯（GO）的、海藻酸钠（ALG）功能化的结肠靶向药物递送系统的开发，该系统负载 5-氟尿嘧啶（5-FU）作为抗癌药物（表示为 GO-ALG/5-FU）。我们的结果表明，所制备的药物递送系统具有更低的毒性和更好的结肠靶向控制释放行为。我们表明，GO-ALG/5-FU 显著抑制肿瘤生长和肝转移，并延长了小鼠的生存时间。我们预计我们的实验将有助于改善结肠靶向药物递送系统的基础研究，并为治疗结肠癌肝转移提供新的途径。
