组胺与哇巴因对心室颤动阈值的协同相互作用。

Synergistic interaction between histamine and ouabain on ventricular fibrillation threshold.

作者信息

Trzeciakowski J P

出版信息

Br J Pharmacol. 1985 May;85(1):21-7. doi: 10.1111/j.1476-5381.1985.tb08826.x.

DOI:10.1111/j.1476-5381.1985.tb08826.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1916752/

Abstract

The interaction between histamine and ouabain on the ventricular fibrillation threshold (VFT) was studied in the isolated, Langendorff-perfused heart of the guinea-pig. When administered separately, histamine and ouabain each reduced the VFT in a concentration-related manner with ED50 values of 84.3 and 250 nM, respectively. When perfused in combination the effects of these two drugs on VFT were significantly greater than the sum of their individual contributions. Mepyramine and cimetidine both antagonized the fibrillatory effects of the histamine-ouabain combination. Neither antagonist affected the fibrillation concentration-response curve for ouabain. These results suggest that both classes of histamine receptor may participate in the histamine-ouabain interaction.

摘要

在豚鼠离体的Langendorff灌注心脏中，研究了组胺与哇巴因对心室颤动阈值（VFT）的相互作用。单独给药时，组胺和哇巴因均以浓度相关的方式降低VFT，其半数有效剂量（ED50）值分别为84.3和250 nM。当联合灌注时，这两种药物对VFT的作用明显大于它们各自作用之和。美吡拉敏和西咪替丁均拮抗组胺 - 哇巴因组合的致颤作用。两种拮抗剂均不影响哇巴因的颤动浓度 - 反应曲线。这些结果表明，两类组胺受体可能都参与了组胺 - 哇巴因的相互作用。

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