Morley J E, Levine A S, Gosnell B A, Krahn D D
Brain Res Bull. 1985 Jun;14(6):511-9. doi: 10.1016/0361-9230(85)90099-1.
During the past decade there has been an increased awareness of the role peptides play as neuromodulators. In this article we review the available data on peptides as central regulators of food ingestion. We stress the possible problems of non-specific effects. We stress that whereas many peptides decrease feeding after central injection, only two families of peptides have been shown to increase feeding after central injection. These are the opioid family and the pancreatic polypeptide-neuropeptide Y family. The putative role of corticotropin releasing factor as the mediator of norepinephrine and serotonin effects on feeding is discussed.
在过去十年中，人们越来越意识到肽作为神经调节剂所起的作用。在本文中，我们综述了有关肽作为食物摄入中枢调节因子的现有数据。我们强调了非特异性效应可能存在的问题。我们强调，虽然许多肽在中枢注射后会减少进食，但只有两类肽在中枢注射后被证明会增加进食。它们是阿片肽家族和胰多肽-神经肽Y家族。本文还讨论了促肾上腺皮质激素释放因子作为去甲肾上腺素和5-羟色胺对进食影响的介质的假定作用。
