Morley J E, Levine A S, Gosnell B A, Mitchell J E, Krahn D D, Nizielski S E
Peptides. 1985;6 Suppl 2:181-92. doi: 10.1016/0196-9781(85)90153-6.
This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated--a peripheral satiety system, typified by the gastrointestinal hormone cholecystokinin and a central feeding system driven by the opioid peptides and neuropeptide Y. This review also discusses the putative role of peptides in the anorexia of aging, drinking elicited by feeding and as mediators of the autonomic effects seen in association with ventromedial hypothalamic lesions.
本报告回顾了肽在食欲调节中发挥作用的假说，强调现有证据主要是药理学方面的，因此目前在赋予其生理意义时需要谨慎。已提出两种肽系统——一种外周饱腹感系统，以胃肠激素胆囊收缩素为代表；另一种是由阿片肽和神经肽Y驱动的中枢进食系统。本综述还讨论了肽在衰老性厌食、进食引起的饮水以及作为与腹内侧下丘脑损伤相关的自主神经效应介质中的假定作用。
