Biostatistics and Epidemiology Department, Gustave Roussy Cancer Center, Villejuif, France.
Université Paris 11 Saclay and INSERM U1018 CESP OncoStat, Villejuif, France.
Clin Cancer Res. 2017 Aug 1;23(15):3977-3979. doi: 10.1158/1078-0432.CCR-17-1306. Epub 2017 Jun 19.
The most commonly used method for dose finding, the 3 + 3, has poor performance. New adaptive designs are more efficient. Nevertheless, they have reached a maximum performance level, and further improvement requires either larger sample sizes or outcomes measures richer than the simplistic severe toxicity measured at cycle 1. .
最常用的剂量确定方法，即 3+3 法，表现不佳。新的适应性设计更有效率。然而，它们已经达到了最高的性能水平，进一步的改进需要更大的样本量或更丰富的结果测量，而不仅仅是简单地在第 1 周期测量严重毒性。
