降钙素、甲状旁腺激素和前列腺素E2对分离破骨细胞环磷酸腺苷水平的影响。
The effects of calcitonin, parathyroid hormone and prostaglandin E2 on cyclic AMP levels of isolated osteoclasts.
作者信息
Ito M B, Schraer H, Gay C V
出版信息
Comp Biochem Physiol A Comp Physiol. 1985;81(3):653-7. doi: 10.1016/0300-9629(85)91043-6.
Cyclic AMP (cAMP) levels were measured in both isolated and attached osteoclasts. The level of cAMP was 0.1 pmol/10(5) osteoclasts. No change in cAMP level of osteoclasts could be detected following calcitonin treatment. Parathyroid hormone (PTH) and prostaglandin E2 (PGE2) treatment stimulated cAMP production in proportion to alkaline phosphatase levels and divergent to acid phosphatase levels. This indicates that osteoblasts, not osteoclasts, were responsive to PTH and PGE2.
在分离的和附着的破骨细胞中均测量了环磷酸腺苷（cAMP）水平。cAMP水平为0.1 pmol/10⁵个破骨细胞。降钙素处理后未检测到破骨细胞cAMP水平的变化。甲状旁腺激素（PTH）和前列腺素E2（PGE2）处理以与碱性磷酸酶水平成比例且与酸性磷酸酶水平不同的方式刺激cAMP产生。这表明对PTH和PGE2有反应的是成骨细胞，而非破骨细胞。
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