侵袭性胎盘形成过程中可溶性fms样酪氨酸激酶1表达的下调
Down-regulation of soluble fms-like tyrosine kinase 1 expression in invasive placentation.
作者信息
Shainker Scott A, Dannheim Katelyn, Gerson Kristin D, Neo Dayna, Zsengeller Zsuzsanna K, Pernicone Elizabeth, Karumanchi S Ananth, Hacker Michele R, Hecht Jonathan L
机构信息
Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, USA.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
出版信息
Arch Gynecol Obstet. 2017 Aug;296(2):257-262. doi: 10.1007/s00404-017-4432-7. Epub 2017 Jun 19.
PURPOSE
To confirm reduced expression of soluble fms-like tyrosine kinase 1 (sFlt-1) in accreta/increta.
METHODS
Formalin-fixed tissue sections from 11 peripartum hysterectomies with invasive placentation and 5 controls were stained for sFlt-1. Stain intensity was scored in selected 100× microscopic fields. We compared sFlt-1 expression in invasive areas among cases, non-invasive areas among cases and areas from control placentas.
RESULTS
Chorionic villi displayed significantly decreased sFlt-1 expression in invasive areas of cases compared to control placentas (p = 0.003), as well as in non-invasive areas of cases compared to control placentas (p = 0.01). There was no difference in sFlt-1 expression between invasive and non-invasive areas among cases.
CONCLUSIONS
Expression of sFlt-1 is diminished in villous trophoblasts from patients with placenta increta or percreta. Local depth of invasion was not associated with sFlt-1 expression, suggesting a more global abnormality across the implantation site rather than localized to areas of histologic invasion.
目的
证实胎盘植入患者中可溶性fms样酪氨酸激酶1（sFlt-1）表达降低。
方法
对11例有侵袭性胎盘植入的围产期子宫切除术标本及5例对照的福尔马林固定组织切片进行sFlt-1染色。在选定的100倍显微镜视野中对染色强度进行评分。我们比较了病例组侵袭区域、病例组非侵袭区域以及对照胎盘区域的sFlt-1表达。
结果
与对照胎盘相比，病例组侵袭区域的绒毛膜绒毛sFlt-1表达显著降低（p = 0.003），病例组非侵袭区域与对照胎盘相比也显著降低（p = 0.01）。病例组侵袭区域和非侵袭区域之间的sFlt-1表达无差异。
结论
胎盘植入或穿透性胎盘植入患者的绒毛滋养层中sFlt-1表达减少。局部侵袭深度与sFlt-1表达无关，提示整个着床部位存在更广泛的异常，而非局限于组织学侵袭区域。
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