Cytochrome P-450-mediated O-demethylation of two ellipticine derivatives. Differential effect of the murine Ah locus phenotype.
作者信息
Roy M, Monsarrat B, Cros S, Lecointe P, Rivalle C, Bisagni E
出版信息
Drug Metab Dispos. 1985 Jul-Aug;13(4):497-502.
PMID:2863116
Abstract
The O-demethylation of two antitumor drugs (9-methoxyellipticine and a 1-polyalkylamino-substituted analog) was studied by incubation with liver microsomes from rats and mice. The former drug underwent a cytochrome P1-450-independent biotransformation in mice, as shown by an indiscriminate response from individuals genetically responsive or nonresponsive to induction by 3-methylcholanthrene. On the other hand, the second drug was O-demethylated only by genetically responsive mice after pretreatment by 3-methylcholanthrene. It was also O-demethylated predominantly in rats pretreated with either 3-methylcholanthrene or Aroclor 1254.
摘要
相似文献
1
Cytochrome P-450-mediated O-demethylation of two ellipticine derivatives. Differential effect of the murine Ah locus phenotype.
Drug Metab Dispos. 1985 Jul-Aug;13(4):497-502.
2
Regulation of hepatic monooxygenases by phenobarbital, 3-methylcholanthrene, and polychlorinated biphenyls in rapid and slow acetylator mice.苯巴比妥、3-甲基胆蒽和多氯联苯对快速和慢速乙酰化小鼠肝脏单加氧酶的调节作用
Drug Metab Dispos. 1985 May-Jun;13(3):354-8.
3
4
5
Effects of induction on the metabolism and cytochrome P-450 binding of harman and other beta-carbolines.
Xenobiotica. 1988 Jul;18(7):785-96. doi: 10.3109/00498258809041717.
6
7
Binding characteristics of 4-S proteins from rat and mouse liver. High affinity of ellipticines.
Eur J Biochem. 1988 Mar 15;172(3):593-9. doi: 10.1111/j.1432-1033.1988.tb13930.x.
8
Albendazole sulfonation by rat liver cytochrome P-450c.
J Pharmacol Exp Ther. 1988 Aug;246(2):758-64.
9
Influence of inducers of monooxygenases on cytotoxic efficiency of ellipticine on leukemia L1210 cells.单加氧酶诱导剂对椭圆玫瑰树碱抗白血病L1210细胞细胞毒作用的影响。
J Natl Cancer Inst. 1981 Oct;67(4):871-6.
10
Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat.戊氧基试卤灵的脱烷基化作用：一种用于测定苯巴比妥及其他外源化学物对大鼠细胞色素P-450诱导作用的快速灵敏检测方法。
Arch Biochem Biophys. 1985 Apr;238(1):43-8. doi: 10.1016/0003-9861(85)90138-9.
Zotero 插件