Mutlu Kadir, Karadas Ulas, Yozgat Yilmaz, Meşe Timur, Demirol Mustafa, Coban Senay, Karadeniz Cem, Özdemir Rahmi, Orbatu Dilek, Karaarslan Utku, Tavli Vedide
a Department of Pediatric Cardiology , Dr. Behcet Uz Children's Hospital , İzmir , Turkey.
b MH Aegean Maternity , Teaching and Training Hospital , İzmir , Turkey.
J Obstet Gynaecol. 2018 Jan;38(1):16-21. doi: 10.1080/01443615.2017.1322564. Epub 2017 Jun 20.
The aim of this study is to detect preeclampsia-related cardiac dysfunction within 24-48 hours of delivery in newborns born from preeclamptic mothers. Forty newborns from mildly preeclamptic mothers formed the study group and the control group was formed by 40 healthy newborns. Cardiac function for the groups were evaluated using conventional echocardiography and myocardial performance index (MPI) within the first 24-48 hours of their lifetime and the results of both groups were compared. A significant difference between the groups was observed especially in the PW Doppler MPI measurements (the left ventricle MPI 0.37 ± 0.09 and 0.26 ± 0.11, p < .001; the right ventricle MPI 0.29 ± 0.08 and 0.26 ± 0.07, p < .035) for the control group and the study group. Elongation in the left and right ventricle MPI was detected to be more significant in terms of comparing systolic and diastolic functions to determine preeclampsia-related cardiac injury in newborns from preeclamptic mothers within the first 24-48 hours of their lifetime. Impact statement Today, the methods which may detect cardiac injury earlier than conventional echocardiographic methods are used for evaluating cardiac functions. Among them, myocardial performance index (MPI) measurement with PW Doppler is the most common ones. While studies are available in the literature evaluating foetal cardiac functions with MPI in foetuses of preeclamptic women, studies evaluating cardiac functions with MPI index within the first 24-48 hours in postnatal period are not available. This is the first study to detect cardiac injury by measuring cardiac functions of the newborns of preeclamptic babies using conventional echocardiography (EF, SF, mitral and tricuspid E/A) and myocardial performance index within the first 24-48 hours of life and compare these values with those of a control group composed of healthy newborns with similar demographic characteristics. According to the results of the study, elongation in right and left ventricle MPI was detected to be more significant compared to systolic and diastolic functions for determining preeclampsia-related cardiac injury in newborns of preeclamptic mothers within 24-48 hours of delivery. Ventricle functions of the newborns of preeclamptic mothers should also be evaluated with MPI measurement besides conventional echocardiographic measurements.
本研究的目的是在子痫前期母亲所生新生儿出生后24至48小时内检测与子痫前期相关的心脏功能障碍。40名轻度子痫前期母亲所生的新生儿组成研究组，40名健康新生儿组成对照组。在两组新生儿出生后的头24至48小时内，使用传统超声心动图和心肌性能指数（MPI）评估其心脏功能，并比较两组结果。两组之间存在显著差异，尤其是在PW多普勒MPI测量方面（对照组左心室MPI为0.37±0.09，研究组为0.26±0.11，p<0.001；对照组右心室MPI为0.29±0.08，研究组为0.26±0.07，p<0.035）。在子痫前期母亲所生新生儿出生后的头24至48小时内，比较收缩和舒张功能以确定与子痫前期相关的心脏损伤时，发现左、右心室MPI的延长更为显著。影响声明如今，人们使用比传统超声心动图方法能更早检测心脏损伤的方法来评估心脏功能。其中，用PW多普勒测量心肌性能指数（MPI）是最常用的方法。虽然文献中有关于用MPI评估子痫前期孕妇胎儿心脏功能的研究，但尚无在出生后24至48小时内用MPI指数评估心脏功能的研究。这是第一项在出生后24至48小时内，通过传统超声心动图（EF、SF、二尖瓣和三尖瓣E/A）和心肌性能指数测量子痫前期母亲所生新生儿的心脏功能，并将这些值与由具有相似人口统计学特征的健康新生儿组成的对照组进行比较来检测心脏损伤的研究。根据研究结果，在分娩后24至48小时内，比较收缩和舒张功能时，发现子痫前期母亲所生新生儿的右、左心室MPI延长更为显著以确定与子痫前期相关的心脏损伤。除了传统超声心动图测量外，还应用MPI测量来评估子痫前期母亲所生新生儿的心室功能。
