Nair Rekha A, Vasudevan Jayasudha Arundhathi, Jacob Priya Mary, Sukumaran Renu
Division of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
Indian J Pathol Microbiol. 2017 Apr-Jun;60(2):206-208. doi: 10.4103/IJPM.IJPM_762_16.
Peripheral T-cell lymphomas (PTCLs) are non-Hodgkin's lymphomas (NHLs) with considerable variation in incidence across the world. They show a wide variety of clinicopathological features and generally associated with poor clinical outcome. Lymphoma data from different geographic regions will definitely aid in routine clinical practice and research work. PTCLs are reported with a higher frequency in Asia as compared to Western countries.
The objective of this study was to analyze the frequency and distribution of PTCLs diagnosed in a tertiary care cancer center in Kerala.
This was a retrospective study carried out in the Division of Pathology, Regional Cancer Centre, Thiruvananthapuram, for 5 years from January 1, 2011, to December 31, 2015. All PTCLs diagnosed during this period were reviewed and then classified according to the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Statistical significance of the results was evaluated using Chi-square test.
Among the total 3108 cases of lymphomas diagnosed at our center, 2404 cases were NHLs (77.35%). PTCLs (n = 333) contributed 13.85% of all NHLs. Among these, PTCL, not otherwise specified, constituted the most common subtype (92 cases, 27.63%), followed by angioimmunoblastic T-cell lymphoma (79 cases, 23.72%), anaplastic large cell lymphoma (75 cases, 22.52%), mycosis fungoides (28 cases, 8.40%), and adult T-cell leukemia/lymphoma (ATLL) (28 cases, 8.40%).
This is the largest study on PTCLs reported from Kerala. We document that the frequency of PTCLs is higher than that reported from Western studies. The frequency of ATLL reported from Kerala is much higher than that reported from other states.
外周T细胞淋巴瘤（PTCL）是非霍奇金淋巴瘤（NHL），在全球发病率差异很大。它们表现出各种各样的临床病理特征，通常与不良临床结局相关。来自不同地理区域的淋巴瘤数据肯定有助于日常临床实践和研究工作。与西方国家相比，亚洲报道的PTCL频率更高。
本研究的目的是分析在喀拉拉邦一家三级医疗癌症中心诊断的PTCL的频率和分布。
这是一项回顾性研究，于2011年1月1日至2015年12月31日在特里凡得琅地区癌症中心病理科进行，为期5年。对在此期间诊断的所有PTCL进行回顾，然后根据2016年世界卫生组织淋巴肿瘤分类修订版进行分类。使用卡方检验评估结果的统计学意义。
在我们中心诊断的3108例淋巴瘤病例中，2404例为NHL（77.35%）。PTCL（n = 333）占所有NHL的13.85%。其中，未另行指定的PTCL构成最常见的亚型（92例，27.63%），其次是血管免疫母细胞性T细胞淋巴瘤（79例，23.72%）、间变性大细胞淋巴瘤（75例，22.52%）、蕈样肉芽肿（28例，8.40%）和成人T细胞白血病/淋巴瘤（ATLL）（28例，8.40%）。
这是喀拉拉邦报道的关于PTCL的最大规模研究。我们记录到PTCL的频率高于西方研究报道的频率。喀拉拉邦报道的ATLL频率远高于其他邦报道的频率。
