Segar Lavanya, Easow Joshy M, Srirangaraj Sreenivasan, Hanifah Mohammad, Joseph Noyal M, Seetha K S
Department of Microbiology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.
Department of Microbiology, Sri Venkateshwaraa Medical College Hospital and Research Centre, Puducherry, India.
Indian J Pathol Microbiol. 2017 Apr-Jun;60(2):221-225. doi: 10.4103/0377-4929.208383.
Clostridium difficile, a most important nosocomial enteric pathogen, is recognized globally as responsible for antibiotic-associated diarrhea and colitis. It is associated with considerable morbidity and mortality due to widespread use of antibiotics.
The study was done to determine the prevalence of C. difficile infection (CDI) among the patients attending a tertiary care teaching hospital in Puducherry.
We performed a prospective cohort study in Mahatma Gandhi Medical College and Research Institute.
Around 150 patients were evaluated along with the patient details. C. difficile toxin detection was done as per the standard algorithm using the C. Diff Quik Chek Complete® assay (TECHLAB, Blacksburg, VA, USA).
Analysis was done using statistics software (SPSS 16.0, SPSS Inc., Chicago, IL, USA).
The prevalence of CDI was found to be 4%. More toxin-positive cases were between 50 and 60 years of age, and there was no difference in gender. Intensive Care Unit showed more toxin-positive cases; however, there was no significant association between the occurrence of CDI and the primary diagnosis of the patients.
The prevalence of CDI in our hospital was found to be 4%, which was relatively lower compared to other Indian studies. However, awareness of the risk factors may assist in identifying patients at higher risk for CDI, guide implementation of appropriate preventive measures, and modulate potential intervention measure during management.
艰难梭菌是一种极为重要的医院内肠道病原体，在全球范围内被认为是导致抗生素相关性腹泻和结肠炎的原因。由于抗生素的广泛使用，它与相当高的发病率和死亡率相关。
本研究旨在确定在本地治里一家三级护理教学医院就诊的患者中艰难梭菌感染（CDI）的患病率。
我们在圣雄甘地医学院和研究所进行了一项前瞻性队列研究。
对约150名患者及其详细信息进行了评估。使用艰难梭菌快速检测完整试剂盒（TECHLAB，美国弗吉尼亚州布莱克斯堡）按照标准算法进行艰难梭菌毒素检测。
使用统计软件（SPSS 16.0，美国伊利诺伊州芝加哥SPSS公司）进行分析。
发现CDI的患病率为4%。毒素阳性病例更多在50至60岁之间，且在性别上无差异。重症监护病房显示出更多毒素阳性病例；然而，CDI的发生与患者的初步诊断之间没有显著关联。
我们医院CDI的患病率为4%，与其他印度研究相比相对较低。然而，对危险因素的认识可能有助于识别CDI高危患者，指导实施适当的预防措施，并在管理过程中调整潜在的干预措施。
