Tuttle J B
Fed Proc. 1985 Sep;44(12):2760-6.
Avian ciliary ganglion neurons in cell culture have been used as a model neuronal system to examine the developmental role of direct contact with an appropriate target tissue. Live myotubes, which are immediately innervated, and their membrane remnants, on which neurons form terminal structures, were both found to stimulate or accelerate the acquisition or retention of important parameters of neuronal function. Contact with the target membrane supports survival, aids retention of active nicotinic receptors to acetylcholine, and accelerates the acquisition of adult transmitter synthetic capacity. These results emphasize the multifaceted nature of neurodevelopment, with soluble protein factors, membrane-bound elements, and other functional events all acting in concert in the embryonic nervous system.
细胞培养中的鸟类睫状神经节神经元已被用作模型神经元系统，以研究与合适的靶组织直接接触在发育过程中的作用。研究发现，立即被神经支配的活肌管及其神经元形成终末结构的膜残余物，均可刺激或加速神经元功能重要参数的获得或保留。与靶膜接触可支持神经元存活，有助于保留对乙酰胆碱有活性的烟碱样受体，并加速成年递质合成能力的获得。这些结果强调了神经发育的多方面性质，可溶性蛋白质因子、膜结合成分和其他功能事件在胚胎神经系统中协同发挥作用。
