感知性语音和言语差异在帕金森病、进行性核上性麻痹和多系统萎缩-帕金森综合征诊断中的实用性和准确性。
Utility and accuracy of perceptual voice and speech distinctions in the diagnosis of Parkinson's disease, PSP and MSA-P.
作者信息
Miller Nick, Nath Uma, Noble Emma, Burn David
机构信息
Newcastle University Institute for Ageing, Speech & Language Sciences, George VI Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Consultant Neurologist, Sunderland Royal Hospital, Kyall Road, Sunderland SR4 7TP, UK.
出版信息
Neurodegener Dis Manag. 2017 Jun;7(3):191-203. doi: 10.2217/nmt-2017-0005. Epub 2017 Jun 20.
AIM
To determine if perceptual speech measures distinguish people with Parkinson's disease (PD), multiple system atrophy with predominant parkinsonism (MSA-P) and progressive supranuclear palsy (PSP).
METHODS
Speech-language therapists blind to patient characteristics employed clinical rating scales to evaluate speech/voice in 24 people with clinically diagnosed PD, 17 with PSP and 9 with MSA-P, matched for disease duration (mean 4.9 years, standard deviation 2.2).
RESULTS
No consistent intergroup differences appeared on specific speech/voice variables. People with PD were significantly less impaired on overall speech/voice severity. Analyses by severity suggested further investigation around laryngeal, resonance and fluency changes may characterize individual groups.
CONCLUSION
MSA-P and PSP compared with PD were distinguished by severity of speech/voice deterioration, but individual speech/voice parameters failed to consistently differentiate groups.
目的
确定感知言语测量是否能区分帕金森病（PD）、以帕金森综合征为主的多系统萎缩（MSA-P）和进行性核上性麻痹（PSP）患者。
方法
对患者特征不知情的言语治疗师使用临床评定量表评估24例临床诊断为PD、17例PSP和9例MSA-P患者的言语/嗓音情况，这些患者的病程相匹配（平均4.9年，标准差2.2）。
结果
在特定言语/嗓音变量上未出现一致的组间差异。PD患者在总体言语/嗓音严重程度方面受损明显较轻。按严重程度进行的分析表明，围绕喉部、共鸣和流畅性变化的进一步研究可能有助于区分各个组。
结论
与PD相比，MSA-P和PSP的区别在于言语/嗓音恶化的严重程度，但个体言语/嗓音参数未能始终如一地区分各组。
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