York Philip J, Wydra Frank B, Belton Matthew E, Vidal Armando F
Department of Orthopedic Surgery, University of Colorado School of Medicine, Aurora, Colorado.
Sports Health. 2017 Nov/Dec;9(6):545-554. doi: 10.1177/1941738117712203. Epub 2017 Jun 20.
With increasing life expectancy, there is growing demand for preservation of native articular cartilage to delay joint arthroplasties, especially in younger, active patients. Damage to the hyaline cartilage of a joint has a limited intrinsic capacity to heal. This can lead to accelerated degeneration of the joint and early-onset osteoarthritis. Treatment in the past was limited, however, and surgical treatment options continue to evolve that may allow restoration of the natural biology of the articular cartilage. This article reviews the most current literature with regard to indications, techniques, and outcomes of these restorative procedures.
MEDLINE and PubMed searches relevant to the topic were performed for articles published between 1995 and 2016. Older articles were used for historical reference. This paper places emphasis on evidence published within the past 5 years.
Clinical review.
Level 4.
Autologous chondrocyte implantation and osteochondral allografts (OCAs) for the treatment of articular cartilage injury allow restoration of hyaline cartilage to the joint surface, which is advantageous over options such as microfracture, which heal with less favorable fibrocartilage. Studies show that these techniques are useful for larger chondral defects where there is no alternative. Additionally, meniscal transplantation can be a valuable isolated or adjunctive procedure to prolong the health of the articular surface.
Newer techniques such as autologous chondrocyte implantation and OCAs may safely produce encouraging outcomes in joint preservation.
随着预期寿命的增加,对于保留天然关节软骨以延缓关节置换术的需求日益增长,尤其是在年轻、活跃的患者中。关节透明软骨损伤后的自我修复能力有限,这可能导致关节加速退变和早发性骨关节炎。过去的治疗方法有限,但手术治疗方案仍在不断发展,可能有助于恢复关节软骨的自然生物学特性。本文回顾了有关这些修复手术的适应症、技术和结果的最新文献。
对1995年至2016年发表的与该主题相关的文章进行了MEDLINE和PubMed检索。较旧的文章用于历史参考。本文重点关注过去5年内发表的证据。
临床综述。
4级。
自体软骨细胞植入和同种异体骨软骨移植(OCA)用于治疗关节软骨损伤可使透明软骨恢复到关节表面,这比微骨折等方法更具优势,微骨折愈合形成的纤维软骨效果较差。研究表明,这些技术对于没有其他选择的较大软骨缺损很有用。此外,半月板移植可以是一种有价值的单独或辅助手术,以延长关节表面的健康时间。
自体软骨细胞植入和OCA等新技术在关节保留方面可能安全地产生令人鼓舞的结果。