Giayetto Víctor O, Blanco Sebastián, Mangeaud Arnaldo, Barbás María G, Cudolá Analía, Gallego Sandra V
Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Laboratorio Central, Ministerio de Salud de la Provincia de Córdoba, Córdoba, Argentina.
Rev Chilena Infectol. 2017 Apr;34(2):108-115. doi: 10.4067/S0716-10182017000200002.
Whooping cough is a re-emerging infection in the world and Latin America.
It was considered relevant to investigate the clinical and epidemiological profile of Bordetella spp. and Bordetella pertussis infection in Córdoba province, Argentina; evaluating, at the same time, the co-infection with virus producing respiratory infections that may be confused with whooping cough.
All whooping cough suspected cases were studied by Polimerase Chain Reaction, amplifying the repeated insertion sequence (IS) 481 and the promoter gene encoding pertussis toxin, between 2011 and 2013. The data were obtained from the clinical and epidemiological records.
From 2,588 whooping cough suspected cases, 11.59% was infected by Bordetella spp. and 9.16% was confirmed as Bordetella pertussis infection. The rate of infection was 7.22 and 1.84 per 100,000 for 2011 and 2012, respectively. The infection presented a seasonal tendency and it was mainly found on the group of children between 13 and 24 months old. The co-infection with virus producing respiratory infections, were uncommon. Paroxysmal cough, cyanosis and/or vomiting were predictors of the infection for Bordetella pertussis.
To deal with the re-emergence of whooping cough is important the knowledge of the regional epidemiological situation. This paper shows the situation of these infections in the regional clinical and epidemiological context, and makes the information available for health decision-making.
百日咳在全球及拉丁美洲再度成为一种感染性疾病。
研究阿根廷科尔多瓦省博德特氏菌属及百日咳博德特氏菌感染的临床和流行病学特征，同时评估与可能与百日咳混淆的引起呼吸道感染的病毒的合并感染情况。
2011年至2013年期间，对所有疑似百日咳病例进行聚合酶链反应研究，扩增重复插入序列（IS）481和编码百日咳毒素的启动子基因。数据来自临床和流行病学记录。
在2588例疑似百日咳病例中，11.59%感染博德特氏菌属，9.16%确诊为百日咳博德特氏菌感染。2011年和2012年的感染率分别为每10万人7.22例和1.84例。感染呈现季节性趋势，主要发生在13至24个月大的儿童群体中。与引起呼吸道感染的病毒的合并感染并不常见。阵发性咳嗽、发绀和/或呕吐是百日咳博德特氏菌感染的预测指标。
了解区域流行病学情况对于应对百日咳的再度出现至关重要。本文展示了这些感染在区域临床和流行病学背景下的情况，并为卫生决策提供了信息。
