Center for Integrated Protein Science Munich (CIPSM), Department Biology II, Ludwig-Maximilians-University Munich, Großhaderner Straße 2, 82152 Planegg-Martinsried, Germany.
Dev Cell. 2017 Jun 19;41(6):573-574. doi: 10.1016/j.devcel.2017.06.002.
Caspases have apoptotic and non-apoptotic functions, both of which depend on their abilities to cleave proteins at specific sites. What distinguishes apoptotic from non-apoptotic substrates has so far been unclear. In this issue of Developmental Cell, Weaver et al. (2017) now provide an answer to this crucial question.
半胱天冬酶具有凋亡和非凋亡功能，这两种功能都依赖于它们在特定位点切割蛋白质的能力。到目前为止，区分凋亡和非凋亡底物的特征还不清楚。在本期《发育细胞》中，Weaver 等人（2017）现在为这个关键问题提供了答案。
