鞘氨醇-1-磷酸作为淋巴细胞的通行票和生存票。

Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive.

机构信息

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

Dev Cell. 2017 Jun 19;41(6):576-578. doi: 10.1016/j.devcel.2017.06.006.

DOI:10.1016/j.devcel.2017.06.006

Abstract

An established role of sphingosine 1-phosphate receptor-1 in T cells is to guide their exit from lymph nodes. Reporting in Nature, Mendoza et al. (2017) now show that lymphatic endothelial sphingosine 1-phosphate signals through sphingosine 1-phosphate receptor-1 to prevent mitochondria degradation and thereby support survival of naive T cells.

摘要

S1P 受体 1 在 T 细胞中的一个既定作用是引导它们从淋巴结中排出。门多萨等人在《自然》杂志上的报告（2017 年）现在表明，淋巴管内皮细胞的 S1P 通过 S1P 受体 1 发出信号，防止线粒体降解，从而支持幼稚 T 细胞的存活。