牛甲状旁腺激素原前体内部同源性的证据。
Evidence for internal homology in bovine preproparathyroid hormone.
作者信息
Cohn D V, Smardo F L, Morrissey J J
出版信息
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1469-71. doi: 10.1073/pnas.76.3.1469.
By means of a statistical method for detecting distant evolutionary relationships between proteins, we found a high probability that internal homologies exist in preproparathyroid hormone, the biological precursor of proparathyroid hormone and parathyroid hormone. The regions so defined were -27 to +22 of preproparathyroid hormone vs. +26 to +74 parathyroid hormone and -23 to +29 of preproparathyroid hormone vs. +30 to +81 of parathyroid hormone. Examination of these regions for possible similarities of internal secondary structure (beta turns, alpha helix, and beta sheet) by a second type of predictive formulation indicated that most of the regions calculated to be related on an evolutionary basis were likewise homologous in terms of structure. These results and other considerations suggest that a primitive form of parathyroid hormone, possibly of pituitary origin, existed (or still exists). Parathyroid hormone of higher species likely was formed by gene doubling and fusion of the primitive gene.
通过一种用于检测蛋白质间远距离进化关系的统计方法，我们发现甲状旁腺激素原和甲状旁腺激素的生物前体——前甲状旁腺激素中存在内部同源性的可能性很高。如此确定的区域为前甲状旁腺激素的-27至+22对应甲状旁腺激素的+26至+74，以及前甲状旁腺激素的-23至+29对应甲状旁腺激素的+30至+81。通过第二种预测公式检查这些区域内部二级结构（β转角、α螺旋和β折叠）的可能相似性，结果表明，在进化基础上计算得出的大多数相关区域在结构上同样是同源的。这些结果及其他考虑因素表明，可能起源于垂体的一种原始形式的甲状旁腺激素曾经存在（或仍然存在）。高等物种的甲状旁腺激素可能是由原始基因的基因加倍和融合形成的。
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