Huang J D, Oie S
J Pharm Pharmacol. 1985 Jul;37(7):471-5. doi: 10.1111/j.2042-7158.1985.tb03042.x.
The effect of changing the protein binding of S-disopyramide, a compound that is highly extracted by the liver on its hepatic clearance in rabbits is described. Using indocyanine green clearance as a means of measuring hepatic blood flow, qualitative changes were observed which are in agreement with the results predicted by both the 'parallel tube' and the 'well-stirred' models. However, neither model alone could explain the quantitative changes. Suggestions are put forward to explain these results.
描述了改变 S-双异丙吡胺（一种肝脏高度摄取的化合物）的蛋白结合对其在兔体内肝清除率的影响。使用吲哚菁绿清除率作为测量肝血流量的方法，观察到的定性变化与“平行管”模型和“充分搅拌”模型预测的结果一致。然而，单独的任何一个模型都无法解释定量变化。文中提出了解释这些结果的建议。
