脑池内注射甘氨酸可激活氨基甲酸乙酯麻醉大鼠的排尿反射。
Intracisternal glycine activates the micturition reflex in urethane-anaesthetized rats.
作者信息
Maggi C A, Furio M, Santicioli P, Meli A
出版信息
J Pharm Pharmacol. 1985 Jul;37(7):517-20. doi: 10.1111/j.2042-7158.1985.tb03058.x.
Abstract
Intracisternal glycine, but not GABA, activates a series of neurogenic rhythmic contractions of the urinary bladder in urethane-anaesthetized rats. This effect of glycine was prevented by strychnine but not by bicuculline, indicating the involvement of specific glycinergic receptors. The effects of glycine were also prevented by either atropine or haloperidol suggesting an involvement of cholinergic and monoaminergic excitatory neurotransmission to the bladder.
摘要
在氨基甲酸乙酯麻醉的大鼠中，脑池内注射甘氨酸而非γ-氨基丁酸（GABA），可激活膀胱一系列神经源性节律性收缩。士的宁可阻断甘氨酸的这一效应，而荷包牡丹碱则不能，这表明存在特定的甘氨酸能受体参与其中。阿托品或氟哌啶醇也可阻断甘氨酸的效应，提示胆碱能和单胺能兴奋性神经传递参与了对膀胱的作用。
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