Stiff Katherine M, Cohen Philip R
Department of Dermatology, University of California San Diego, La Jolla, California.
Dermatol Online J. 2017 Jun 15;23(6):13030/qt9tv6p5jz.
BackgroundHerpes zoster vaccine is currently recommended in the United States for immune competent individuals ≥60 years. The efficacy of the herpes zoster vaccine decreases with age and with time following vaccination.PurposeAn elderly man with herpes zoster following vaccination is described. The guidelines for vaccination and issues regarding re-vaccination are reviewed.
PubMed was used to search the following terms: efficacy, elderly, herpes zoster, herpes zoster incidence, herpes zoster recurrence, and vaccination. The papers and relevant citations were reviewed. The clinical features of a patient with post-vaccination herpes zoster skin infection are presented; in addition, vaccine efficacy and guidelines are reviewed.ResultsA 91-year-old man, vaccinated for herpes zoster 10 years earlier, presented with crusted erosions on his face corresponding to the area innervated by the ophthalmic division of the left trigeminal nerve. Evaluation using polymerase chain reaction confirmed the diagnosis of herpes zoster.ConclusionsHerpes zoster vaccine decreases in efficacy with both age and number of years following vaccination. Therefore, booster shots or revaccination in the older population may be of benefit.
背景
目前美国推荐≥60岁免疫功能正常的个体接种带状疱疹疫苗。带状疱疹疫苗的效力会随着年龄增长以及接种后的时间推移而降低。
目的
描述一名接种疫苗后发生带状疱疹的老年男性。回顾疫苗接种指南以及再次接种相关问题。
方法
使用PubMed搜索以下术语：效力、老年人、带状疱疹、带状疱疹发病率、带状疱疹复发及疫苗接种。对相关论文及引用文献进行回顾。呈现一名接种后发生带状疱疹皮肤感染患者的临床特征；此外，对疫苗效力及指南进行回顾。
结果
一名91岁男性，10年前接种过带状疱疹疫苗，其面部出现结痂性糜烂，对应左侧三叉神经眼支支配区域。采用聚合酶链反应进行评估确诊为带状疱疹。
结论
带状疱疹疫苗的效力随年龄增长以及接种后的年数而降低。因此，对老年人群进行加强接种或再次接种可能有益。
