Ahmed Idris Adewale, Mikail Maryam Abimbola, Ibrahim Muhammad
Department of Nutrition Sciences, International Islamic University Malaysia (IIUM); Department of Biotechnology, Lincoln University College, Malaysia.
Department of Nutrition Sciences, International Islamic University Malaysia (IIUM).
Nutr Res. 2017 Jun;42:31-42. doi: 10.1016/j.nutres.2017.04.012. Epub 2017 May 5.
Hypercholesterolemia is an important risk factor linked to the alteration of blood hematology and clinical chemistry associated with the development and progression of atherosclerosis. Previous studies have demonstrated the safety and potential health benefits of Baccaurea angulata (BA) fruit. We hypothesized that the oral administration of BA fruit juice could ameliorate the alteration in the hematological and biochemical biomarkers of diet-induced hypercholesterolemic rabbits. The aim of this study was to investigate the effects of different doses of BA juice on the hematological and biochemical biomarkers in normo- and hypercholesterolemic rabbits. Thirty-five healthy adult New Zealand White rabbits were assigned to seven different groups for 90days of diet intervention. Four atherogenic groups were fed a 1% cholesterol diet and 0, 0.5, 1.0, and 1.5mL of BA juice per kg of rabbit daily. The other three normal groups were fed a commercial rabbit pellet diet and 0, 0.5, and 1.0mL of BA juice per kg of rabbit daily. Baseline and final blood samples after 90days of repeated administration BA juice were analyzed for hematological parameters while serum, aortic and hepatic lysates were analyzed for lipid profiles and other biochemical biomarkers. The alteration of the hemopoietic system, physiological changes in serum and tissues lipid profiles and other biochemicals resulting from the consumption of a high-cholesterol diet were significantly (P<.05) ameliorated by the administration of BA juice. Improvements of the biomarkers in rabbits were dose-dependent, markedly enhanced at the highest dose of juice (1.5mL/kg/day). The results suggest potential health benefits of the antioxidant-rich BA fruit juice against hypercholesterolemia-associated hematological and biochemical alterations in the rabbit.
高胆固醇血症是与动脉粥样硬化的发生和发展相关的血液血液学和临床化学改变的重要危险因素。先前的研究已经证明了多花山竹子（BA）果实的安全性和潜在的健康益处。我们假设口服BA果汁可以改善饮食诱导的高胆固醇血症兔子的血液学和生化生物标志物的改变。本研究的目的是调查不同剂量的BA果汁对正常和高胆固醇血症兔子的血液学和生化生物标志物的影响。将35只健康的成年新西兰白兔分配到七个不同的组中进行90天的饮食干预。四个致动脉粥样硬化组每天每公斤兔子喂食1%胆固醇饮食和0、0.5、1.0和1.5mL的BA果汁。其他三个正常组每天每公斤兔子喂食商业兔颗粒饲料和0、0.5和1.0mL的BA果汁。在重复给予BA果汁90天后，对基线和最终血液样本进行血液学参数分析，同时对血清、主动脉和肝脏裂解物进行脂质谱和其他生化生物标志物分析。通过给予BA果汁，高胆固醇饮食导致的造血系统改变、血清和组织脂质谱及其他生化物质的生理变化得到了显著改善（P<0.05）。兔子中生物标志物的改善呈剂量依赖性，在最高剂量的果汁（1.5mL/kg/天）时显著增强。结果表明，富含抗氧化剂的BA果汁对兔子高胆固醇血症相关的血液学和生化改变具有潜在的健康益处。
