Bristow M R, Kantrowitz N E, Ginsburg R, Fowler M B
J Mol Cell Cardiol. 1985 Jul;17 Suppl 2:41-52. doi: 10.1016/0022-2828(85)90007-0.
Using data derived from clinical and experimental observations, we examine the role of the myocardial beta-adrenergic receptor system in pathophysiologic processes involved in heart muscle disease and heart failure. The available data suggest that the sympathetic nervous system exerts important influences on myocardial structure and function. As such the beta-adrenergic pathways represents an obvious locus for therapeutic intervention in evolving cardiomyopathic states.
利用来自临床和实验观察的数据，我们研究了心肌β-肾上腺素能受体系统在涉及心肌疾病和心力衰竭的病理生理过程中的作用。现有数据表明，交感神经系统对心肌结构和功能有重要影响。因此，β-肾上腺素能通路是对正在发展的心肌病状态进行治疗干预的一个明显靶点。
