伴有肝转移的鼻咽癌神经内分泌癌的临床免疫表型
Clinical immunophenotype of nasopharyngeal neuroendocrine carcinoma with metastatic liver cancer.
作者信息
Guo Chao, Pan Qijin, Su Min, Li Rong
机构信息
Department of Pharmacy, Guigang City People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, Guangxi, PR China.
Department of Oncology, Guigang City People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, Guangxi, PR China.
出版信息
Clin Chim Acta. 2017 Aug;471:283-285. doi: 10.1016/j.cca.2017.06.016. Epub 2017 Jun 17.
BACKGROUND
Nasopharyngeal neuroendocrine carcinoma (NNC) refers to a rare and lethal cancer, characterized with high risk of metastases. Here, we report a case of nasopharyngeal neuroendocrine carcinoma with subsequent liver metastases to discuss its clinical immunophenotype and challenges.
METHODS
In clinical biochemical assays, hematological determination, immunohistochemical examination, imaging medicine investigations, and therapeutical analysis were subjected to the hospitalized patient, respectively.
RESULTS
A group of clinical detectable data highlighted that clinical immunophenotype of nasopharyngeal neuroendocrine carcinoma was identified in immunohistochemical inspection, followed by validation of liver metastases via imaging observations. Subsequent chemotherapy schedule showed disease remission in certain aspect before patient' death.
CONCLUSION
Our current clinical data disclose that it is vital to identify nasopharyngeal neuroendocrine carcinoma for main cause of liver metastases with potential risk. Further, early diagnosis and effective pharmacotherapy may improve the survival rate of NNC patient with liver metastases.
背景
鼻咽神经内分泌癌（NNC）是一种罕见的致命癌症，其特征是转移风险高。在此，我们报告一例鼻咽神经内分泌癌继发肝转移的病例，以探讨其临床免疫表型及面临的挑战。
方法
对该住院患者分别进行临床生化检测、血液学测定、免疫组化检查、影像医学检查及治疗分析。
结果
一组临床可检测数据表明，免疫组化检查确定了鼻咽神经内分泌癌的临床免疫表型，随后通过影像学观察证实了肝转移。后续化疗方案在患者死亡前在一定程度上显示出疾病缓解。
结论
我们目前的临床数据表明，识别鼻咽神经内分泌癌作为肝转移的主要原因及潜在风险至关重要。此外，早期诊断和有效的药物治疗可能提高发生肝转移的鼻咽神经内分泌癌患者的生存率。
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