Lang Chao, Mohite Amar, Deng Xiaoli, Yang Feihu, Dong Zeyuan, Xu Jiayun, Liu Junqiu, Keinan Ehud, Reany Ofer
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, China.
Chem Commun (Camb). 2017 Jul 4;53(54):7557-7560. doi: 10.1039/c7cc04026a.
Semithiobambus[6]uril is shown to be an efficient transmembrane anion transporter. Although all bambusuril analogs (having either O, S or N atoms in their portals) are excellent anion binders, only the sulfur analog is also an effective anion transporter capable of polarizing lipid membranes through selective anion uniport. This notable divergence reflects significant differences in the lipophilic character of the bambusuril analogs.
半硫代杯[6]芳烃被证明是一种高效的跨膜阴离子转运体。尽管所有的杯芳烃类似物(在其入口处含有氧、硫或氮原子)都是优秀的阴离子结合剂,但只有硫代类似物也是一种有效的阴离子转运体,能够通过选择性阴离子单向转运使脂质膜极化。这种显著的差异反映了杯芳烃类似物在亲脂性方面的重大差异。