Wu Y L, Sun J M, Zhang J J, Cui Q X, Zheng W H, Li X R
Department of Thyroid and Breast Surgery, Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jun 7;52(6):426-429. doi: 10.3760/cma.j.issn.1673-0860.2017.06.006.
To analyze the clinicopathological characteristics of papillary thyroid microcarcinoma (PTMC) and risk factors for central lymph node metastasis(CLNM) in PTMC. The data of 900 patients with PTMC initially treated in our hospital from January 2004 to December 2015 were retrospectively analyzed. Chi-square test and Logistic regression analysis were performed to determine the risk factors for CLNM. CLNM affected 162 (22.9%) of 707 patients treated with central lymph node dissection. Age, maximum tumor size, multifocality, bilaterality, and extracapsular spread (ECS) were significantly correlated with CLNM (all <0.01). Age<45 years, maximum tumor size>5 mm, multifocality, bilaterality, and extracapsular spread were independently correlated with CLNM. A prophylactic central lymph node dissection should be considered in PTMC patients with age<45 years, maximum tumor size>5 mm, multifocality, bilaterality, and extracapsular spread.
分析甲状腺微小乳头状癌（PTMC）的临床病理特征及PTMC中央区淋巴结转移（CLNM）的危险因素。回顾性分析2004年1月至2015年12月在我院初治的900例PTMC患者的数据。采用卡方检验和Logistic回归分析确定CLNM的危险因素。在707例行中央区淋巴结清扫术的患者中，162例（22.9%）发生CLNM。年龄、最大肿瘤直径、多灶性、双侧性和包膜外侵犯（ECS）与CLNM显著相关（均P<0.01）。年龄<45岁、最大肿瘤直径>5 mm、多灶性、双侧性和包膜外侵犯与CLNM独立相关。对于年龄<45岁、最大肿瘤直径>5 mm、多灶性、双侧性和包膜外侵犯的PTMC患者，应考虑行预防性中央区淋巴结清扫术。
