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J Int Med Res. 2017 Dec;45(6):2146-2152. doi: 10.1177/0300060517710407. Epub 2017 Jun 21.
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Single-Center Experience of ABO-Incompatible Living-Donor Liver Transplantation With a New Simplified Intravenous Immunoglobulin Protocol: A Propensity Score-Matching Analysis.采用新的简化静脉注射免疫球蛋白方案的ABO血型不相容活体肝移植单中心经验：倾向评分匹配分析
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Epidemiology and risk factors for infection after living donor liver transplantation.活体肝移植术后感染的流行病学及危险因素
Liver Transpl. 2017 Apr;23(4):465-477. doi: 10.1002/lt.24739.
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Asplenic patients and invasive pneumococcal disease-how bad is it these days?无脾患者与侵袭性肺炎球菌疾病——如今情况有多糟糕？
Int J Infect Dis. 2016 Oct;51:27-30. doi: 10.1016/j.ijid.2016.08.022. Epub 2016 Aug 30.
3
Splenectomy is not indicated in living donor liver transplantation.脾切除术不适用于活体供肝肝移植。
Liver Transpl. 2016 Nov;22(11):1526-1535. doi: 10.1002/lt.24489.
4
Feasible usage of ABO incompatible grafts in living donor liver transplantation.ABO血型不相容移植物在活体肝移植中的可行应用。
Hepatobiliary Surg Nutr. 2016 Apr;5(2):91-7. doi: 10.3978/j.issn.2304-3881.2015.06.02.
5
ABO-Incompatible Adult Living Donor Liver Transplantation Under the Desensitization Protocol With Rituximab.在使用利妥昔单抗的脱敏方案下进行的ABO血型不相合成人活体肝移植
Am J Transplant. 2016 Jan;16(1):157-70. doi: 10.1111/ajt.13444. Epub 2015 Sep 15.
6
Results of ABO-incompatible liver transplantation using a simplified protocol at a single institution.在单一机构使用简化方案进行ABO血型不相容肝移植的结果。
Transplant Proc. 2015 Apr;47(3):723-6. doi: 10.1016/j.transproceed.2015.02.004.
7
Liver transplantation with deceased ABO-incompatible donors is life-saving but associated with increased risk of rejection and post-transplant complications.使用已故ABO血型不相合供体进行肝移植可挽救生命，但与排斥反应及移植后并发症风险增加相关。
Transpl Int. 2015 Jul;28(7):800-12. doi: 10.1111/tri.12552.
8
ABO-incompatible liver transplantation for severe hepatitis B patients.ABO血型不相容肝移植治疗重型乙型肝炎患者。
Transpl Int. 2015 Jul;28(7):793-9. doi: 10.1111/tri.12531. Epub 2015 Feb 17.
9
Kinetics of B, T, NK lymphocytes and isoagglutinin titers in ABO incompatible living donor liver transplantation using rituximab and basiliximab.使用利妥昔单抗和巴利昔单抗的ABO血型不相容活体供肝移植中B淋巴细胞、T淋巴细胞、自然杀伤细胞的动力学及同种凝集素滴度
Transpl Immunol. 2015 Jan;32(1):29-34. doi: 10.1016/j.trim.2014.11.216. Epub 2014 Nov 20.
10
Hemostatic status in liver transplantation: association between preoperative procoagulants/anticoagulants and postoperative hemorrhaging/thrombosis.肝移植中的止血状态：术前促凝剂/抗凝剂与术后出血/血栓形成之间的关联。
Liver Transpl. 2015 Feb;21(2):258-65. doi: 10.1002/lt.24038. Epub 2015 Jan 13.

中国两例不进行血浆置换的同时性ABO血型不相容活体肝移植及脾切除术病例报告。

Simultaneous ABO-incompatible living-donor liver transplantation and splenectomy without plasma exchange in China: Two case reports.

作者信息

Chen Guoyong, Sun Janjun, Wei Sidong, Chen Yongfeng, Tang Gaofeng, Xie Zhantao, Xu Huaen, Chen Janbin, Zhao Huibo, Yuan Zhenhua, Wang Weiwei, Liu Guangbo, Wang Bing, Niu Biao

机构信息

1 Department of Hepatobiliary and Pancreatic Surgery, People's Hospital, Zhengzhou University, Zhengzhou, China.

2 Department of Hepatobiliary and Pancreatic Surgery, Zhengzhou People's Hospital, Southern Medical University, Zhengzhou, China.

出版信息

J Int Med Res. 2017 Dec;45(6):2146-2152. doi: 10.1177/0300060517710407. Epub 2017 Jun 21.

DOI:10.1177/0300060517710407
PMID:28635356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5805207/
Abstract

ABO-incompatible (ABO-i) living-donor liver transplantation (LDLT) is performed if an ABO-compatible graft cannot be obtained. However, a perfect desensitization protocol has not been established worldwide, especially for simultaneous ABO-i LDLT and splenectomy. We herein report two cases of ABO-i LDLT. To the best of our knowledge, this is the first case report of ABO-i LDLT in an adult patient in China. Splenectomy and T-cell-targeted immunosuppression (basiliximab) was used to overcome the blood group barrier in these recipients. The patients had good graft function without signs of antibody-mediated rejection throughout the 12-month follow-up. Thus, ABO-i LDLT with splenectomy is undoubtedly life-saving when an ABO-compatible graft cannot be obtained for patients in critical condition.

摘要

如果无法获得 ABO 血型相容的供肝，则进行 ABO 血型不相容（ABO-i）活体肝移植（LDLT）。然而，目前全球尚未建立完善的脱敏方案，尤其是对于同期 ABO-i LDLT 和脾切除术而言。我们在此报告两例 ABO-i LDLT 病例。据我们所知，这是中国首例成人 ABO-i LDLT 病例报告。在这些受者中，采用脾切除术和靶向 T 细胞的免疫抑制（巴利昔单抗）来克服血型障碍。在为期 12 个月的随访中，患者移植肝功能良好，未出现抗体介导排斥反应的迹象。因此，对于病情危急且无法获得 ABO 血型相容供肝的患者，ABO-i LDLT 联合脾切除术无疑是挽救生命的方法。