绝经前女性子宫肌瘤栓塞术后的卵巢储备功能
Ovarian reserve after fibroid embolization in premenopausal women.
作者信息
Tsikouras Panagiotis, Manav Bachar, Koukouli Zacharoula, Trypsiannis Grigorios, Galazios Georgios, Souftas Dimitrios, Souftas Vasileios
机构信息
a Department of Obstetrics and Gynaecology , Democritus University of Thrace , Alexandroupolis , Greece.
b Department of Medical Statistics, Medical Faculty , Democritus University of Thrace , Alexandroupolis , Greece.
出版信息
Minim Invasive Ther Allied Technol. 2017 Oct;26(5):284-291. doi: 10.1080/13645706.2017.1292919. Epub 2017 Feb 24.
OBJECTIVE
To investigate the effect of uterine artery embolization (UAE) for fibroids on ovarian pool of premenopausal women.
STUDY DESIGN
Prospective case control study.
MATERIAL AND METHODS
One-hundred and twenty premenopausal women, aged between 40 and 50 years, who underwent UAE for symptomatic uterine fibroids and the same number of women, aged between 40 and 50 years, with symptomatic uterine fibroids, who were not offered treatment were recruited for this study. Hormonal status and ovarian reserve were evaluated by means of anti-Müllerian hormone (AMH) and follicle stimulating hormone (FSH) pre-procedural, three months, six months and 12 months after UAE.
RESULTS
No statistically significant decrease was noted in AMH values 12 months post procedure and no statistical significant alterations in AMH values between the two groups.
CONCLUSIONS
Even though the study results may not be able to confirm the preservation of ovarian reserve and normal menstruation after UAE in premenopausal women, it should be considered as a friendly to normal menstruation treatment option of symptomatic fibroids.
目的
探讨子宫动脉栓塞术（UAE）治疗子宫肌瘤对绝经前女性卵巢储备的影响。
研究设计
前瞻性病例对照研究。
材料与方法
招募120名年龄在40至50岁之间、因有症状的子宫肌瘤接受UAE治疗的绝经前女性，以及相同数量、年龄在40至50岁之间、有症状的子宫肌瘤但未接受治疗的女性参与本研究。在术前、UAE术后3个月、6个月和12个月，通过抗苗勒管激素（AMH）和促卵泡生成素（FSH）评估激素状态和卵巢储备。
结果
术后12个月AMH值无统计学意义的下降，两组间AMH值无统计学意义的改变。
结论
尽管研究结果可能无法证实绝经前女性UAE术后卵巢储备和正常月经得以保留，但UAE应被视为一种对有症状子宫肌瘤的月经友好型治疗选择。
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