Arica Pinar Cigdem, Aydin Seval, Zengin Ulgen, Kocael Ahmet, Orhan Anil, Zengin Kagan, Gelisgen Remise, Taskin Mustafa, Uzun Hafize
a Department of Surgery , Cerrahpasa Medical Faculty, Istanbul University , Istanbul , Turkey.
b Department of Biochemistry , Cerrahpasa Medical Faculty, Istanbul University , Istanbul , Turkey.
J Invest Surg. 2018 Apr;31(2):89-95. doi: 10.1080/08941939.2017.1280564. Epub 2017 Feb 10.
The aim of this study was to examine the relationship between weight loss and resistin, apelin, chemerin, and visfatin after laparoscopic adjustable gastric banding (LAGB).
The study group consisted of 19 patients who were operated on for morbid obesity (BMI: 48.7 ± 6.6 kg/m), and 22 healthy, normal-weight (BMI: 22.9 ± 2.5 kg/m) subjects formed the control group. We obtained blood samples from the study subjects at three different times: before undergoing surgery and at one month and 6 months after surgery. Blood was obtained once from the control group.
Significant weight loss was achieved at one and 6 months after surgery. Plasma levels of apelin, resistin, chemerin, and visfatin were higher in morbidly obese patients compared with the control group. Obesity-related peptides decreased one month and 6 months after surgery.
Elevated plasma resistin, apelin, chemerin, and visfatin levels in morbidly obese patients are gradually reduced after weight loss. According to these findings, LAGB surgery is found to be an important and efficient means for morbidly obese patients both to lose weight and to develop a better metabolic risk profile in a short time period.
本研究旨在探讨腹腔镜可调节胃束带术（LAGB）后体重减轻与抵抗素、脂联素、趋化素和内脂素之间的关系。
研究组由19例接受过病态肥胖手术的患者（BMI：48.7±6.6kg/m²）组成，22例健康、体重正常的受试者（BMI：22.9±2.5kg/m²）作为对照组。我们在三个不同时间点采集研究对象的血样：手术前、手术后1个月和6个月。对照组仅采集一次血样。
术后1个月和6个月体重显著减轻。与对照组相比，病态肥胖患者血浆中的脂联素、抵抗素、趋化素和内脂素水平更高。术后1个月和6个月，肥胖相关肽水平下降。
病态肥胖患者血浆中升高的抵抗素、脂联素、趋化素和内脂素水平在体重减轻后逐渐降低。根据这些发现，LAGB手术被认为是病态肥胖患者在短时间内减肥并改善代谢风险状况的一种重要且有效的方法。
