Rahnasto-Rilla Minna K, McLoughlin Padraig, Kulikowicz Tomasz, Doyle Maire, Bohr Vilhelm A, Lahtela-Kakkonen Maija, Ferrucci Luigi, Hayes Maria, Moaddel Ruin
Biomedical Research Center, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
School of Pharmacy, University of Eastern Finland, Kuopio FI-70210, Finland.
Mar Drugs. 2017 Jun 21;15(6):190. doi: 10.3390/md15060190.
Brown seaweeds contain many bioactive compounds, including polyphenols, polysaccharides, fucosterol, and fucoxantin. These compounds have several biological activities, including anti-inflammatory, hepatoprotective, anti-tumor, anti-hypertensive, and anti-diabetic activity, although in most cases their mechanisms of action are not understood. In this study, extracts generated from five brown algae (, (Linnaeus), , , ) were tested for their ability to activate SIRT6 resulting in H3K9 deacetylation. Three of the five macroalgal extracts caused a significant increase of H3K9 deacetylation, and the effect was most pronounced for . The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan.
褐藻含有许多生物活性化合物，包括多酚、多糖、岩藻甾醇和岩藻黄质。这些化合物具有多种生物活性，包括抗炎、保肝、抗肿瘤、抗高血压和抗糖尿病活性，尽管在大多数情况下其作用机制尚不清楚。在本研究中，测试了从五种褐藻（ 、 （林奈）、 、 、 ）中提取的提取物激活SIRT6导致H3K9去乙酰化的能力。五种大型藻类提取物中有三种导致H3K9去乙酰化显著增加，其中 的效果最为明显。通过质谱鉴定出负责这种体外活性的化合物为岩藻依聚糖。
