[帕金森病冲动控制障碍的预测因素与调节因素]

[Predictors and modifiers of impulse control disorders in Parkinson`s disease].

作者信息

Sapronova M R, Shnayder N A

机构信息

Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.

Clinical Hospital #51, Zheleznogorsk, Krasnoyarsk region, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(11):145-156. doi: 10.17116/jnevro2016116111145-156.

DOI:10.17116/jnevro2016116111145-156

PMID:28635753

Abstract

Impulse control disorders (ICDs), including compulsive gambling, buying, sexual behavior, and eating, are a serious and increasingly recognized psychiatric complication in Parkinson's disease (PD). ICDs have been most closely related to the use of dopamine agonists (DAs), perhaps more so at higher doses. Possible predictor's for ICDs include male sex, younger age and younger age at PD onset, use of dopaminergic agents. Modifiers of ICDs are pharmacological (medication) and non-pharmacological (surgical, behavioral) treatments.

摘要

冲动控制障碍（ICDs），包括强迫性赌博、购物、性行为和饮食，是帕金森病（PD）中一种严重且日益被认识到的精神并发症。ICDs与多巴胺激动剂（DAs）的使用关系最为密切，可能在高剂量时更是如此。ICDs的可能预测因素包括男性、较年轻的年龄以及PD发病时较年轻的年龄、多巴胺能药物的使用。ICDs的调节因素是药物（药物治疗）和非药物（手术、行为）治疗。