Alifirova V M, Zhukova N G, Zhukova I A, Latypova A V, Titova M A, Mironova Yu S, Izhboldina O P, Nikitina M A, Petrov V A
Siberian State Medical University, Tomsk, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(11):174-179. doi: 10.17116/jnevro2016116111174-179.
Microbiota is a community of microorganisms, viruses, protozoa, colonizing the gut. There are tight phylogenetic relationships between the gut microbiota and the human body, the disturbance of which may lead to the CNS dysfunction as well as to the development of neurodegenerative diseases. This review focuses on general and specific aspects of the influence of gut microbiota on the pathogenesis of Parkinson's disease (PD). Current theories and models of the relationship between microbiota and brain structures in PD are presented with a specific focus on neurochemical and immunological aspects of the problem.
微生物群是由定殖于肠道的微生物、病毒、原生动物组成的群落。肠道微生物群与人体之间存在紧密的系统发育关系，其紊乱可能导致中枢神经系统功能障碍以及神经退行性疾病的发生。本综述重点关注肠道微生物群对帕金森病（PD）发病机制影响的一般和特定方面。阐述了PD中微生物群与脑结构关系的当前理论和模型，特别关注该问题的神经化学和免疫学方面。
