Makatsaria A D, Akin'shina S V, Bitsadze V O
Sechenov First Moscow State Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(8 Pt 2):33-39. doi: 10.17116/jnevro20161168233-39.
The review presents literature data on the risk factors of cerebral venous thrombosis (CVT), a rare life threatening disorder. Currently, the diagnosis of CVT is made more often due to the possibility of using neuroimaging methods of cerebral structures. Pregnancy, postpartum period, use of oral contraceptives are risk factors of CVT. A role of thrombophilia, in particular Factor V Leiden mutations and the prothrombin G20210A polymorphism, in the CVT pathogenesis is confirmed. The development of CVT is an example of the interaction between persistent risk factors increasing the likelihood of thrombotic complications and acquired risk factors. A focal neurological deficit during pregnancy, delivery and postpartum period is the best indicator of CVT diagnosis. Possibilities of the use of anticoagulants in treatment and prevention of CVT are analyzed.
本综述介绍了关于脑静脉血栓形成（CVT）危险因素的文献数据，CVT是一种罕见的危及生命的疾病。目前，由于能够使用脑部结构的神经影像学方法，CVT的诊断更为常见。妊娠、产后期、口服避孕药的使用是CVT的危险因素。血栓形成倾向，特别是因子V莱顿突变和凝血酶原G20210A多态性在CVT发病机制中的作用已得到证实。CVT的发生是持续危险因素增加血栓并发症可能性与获得性危险因素之间相互作用的一个例子。妊娠、分娩和产后期出现的局灶性神经功能缺损是CVT诊断的最佳指标。分析了使用抗凝剂治疗和预防CVT的可能性。
