Shavlovskaya O A
Sechenov First Moscow State Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(6):93-97. doi: 10.17116/jnevro20161166193-97.
The review presents data on the evaluation of the efficacy of citicoline in ischemic stroke. It presents research findings about the effect of citicoline to reduce infarct volume in animal models of cerebral ischemia. Long-term treatment of CDP-choline initiated 24 hours after stroke contributes to the increased plasticity of neurons in intact brain areas (functionally associated with the damaged areas) and accelerated functional recovery. The oral administration of citicoline within the first 24 hours after the onset of symptoms in moderate and severe stroke increases the probability of complete recovery in 3 months. A neuroprotective effect of citicoline in acute and early restorative stages of stroke accompanied by cognitive impairment was shown. According to the results of clinical trials of the dosage regimen, citicoline administered in the dose of 1000 mg/day for 8 weeks accelerates the regression of hemiplegia; the intravenous injection in the dose of 750 mg/day for 10 days, starting with the first 48 hours of stroke onset symptoms, promotes the recovery of motor and cognitive functions; the intravenous injection in the dose of 1 g within 14 days improves the recovery of consciousness, general condition and functional status.
该综述展示了关于胞磷胆碱在缺血性卒中疗效评估的数据。它呈现了胞磷胆碱在脑缺血动物模型中减少梗死体积作用的研究结果。卒中后24小时开始长期使用胞磷胆碱有助于完整脑区（与受损区域功能相关）神经元可塑性增加及功能恢复加速。在中度和重度卒中症状出现后的头24小时内口服胞磷胆碱可增加3个月内完全恢复的可能性。已表明胞磷胆碱在伴有认知障碍的卒中急性和早期恢复阶段具有神经保护作用。根据剂量方案的临床试验结果，每天1000毫克剂量的胞磷胆碱持续给药8周可加速偏瘫的消退；从卒中发作症状的头48小时开始，每天750毫克剂量静脉注射10天可促进运动和认知功能的恢复；14天内每天1克剂量静脉注射可改善意识、一般状况和功能状态的恢复。
