Vakhnina N N, Zakharov V V
Sechenov First Moscow Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(1):78-84. doi: 10.17116/jnevro20171171178-84.
Disturbances of gait and postural stability are characteristic of the chronic progressive vascular lesion of the brain observed in moderate to severe stages of cerebrovascular disease. Disconnections between the prefrontal cortex, basal ganglia and cerebellum due to the damage of the white matter (vascular leukoencephalopathy) underlie disturbances of gait and postural stability (shorter stride length, wider gait). There are difficulties in starting with possible stoppings during the walking, waiting in front of small barriers as well as difficulties in concentration (e.g., talk during walking worsen the gait). In contrast to Parkinson's disease, associated movements of hands are observed. The severity of gait disturbances is usually correlated with the severity of vascular cognitive impairment unified by the common underlying substrate - the dysfunction of the frontal brain lobes. Approaches to treatment of patients with vascular movement disorders are discussed.
步态和姿势稳定性障碍是脑血管疾病中重度阶段所观察到的慢性进行性脑血管病变的特征。白质损伤(血管性白质脑病)导致前额叶皮质、基底神经节和小脑之间的联系中断,这是步态和姿势稳定性障碍(步幅缩短、步态变宽)的基础。行走时起始困难,可能会出现停顿,在小障碍物前等待也有困难,并且存在注意力不集中的问题(例如,行走时交谈会使步态变差)。与帕金森病不同,会观察到手部的伴随运动。步态障碍的严重程度通常与由共同潜在底物——额叶功能障碍所统一的血管性认知障碍的严重程度相关。本文讨论了血管性运动障碍患者的治疗方法。